[HTML][HTML] Pharmacokinetic aspects of retinal drug delivery

EM Del Amo, AK Rimpelä, E Heikkinen, OK Kari… - Progress in retinal and …, 2017 - Elsevier
Drug delivery to the posterior eye segment is an important challenge in ophthalmology,
because many diseases affect the retina and choroid leading to impaired vision or …

The use of TPGS in drug delivery systems to overcome biological barriers

MT Luiz, LD Di Filippo, RC Alves, VHS Araújo… - European Polymer …, 2021 - Elsevier
Nanotechnology has been applied in the medicine field to improve the treatment of a wide
range of diseases. However, to reach the nanomedicines delivery to desirable target tissue …

Polymer-based carriers for ophthalmic drug delivery

JC Imperiale, GB Acosta, A Sosnik - Journal of controlled release, 2018 - Elsevier
Despite the wide range of diseases affecting the eye, ocular bioavailability remains a
challenge in ophthalmic drug delivery. Nowadays an extensive variety of polymers are being …

Intraocular nano-microscale drug delivery systems for glaucoma treatment: design strategies and recent progress

Y Shen, J Sun, X Sun - Journal of Nanobiotechnology, 2023 - Springer
Glaucoma is a leading cause of irreversible visual impairment and blindness, affecting over
76.0 million people worldwide in 2020, with a predicted increase to 111.8 million by 2040 …

Nanomaterials for ocular drug delivery

S Liu, L Jones, FX Gu - Macromolecular bioscience, 2012 - Wiley Online Library
Efficient drug delivery to the eye remains a challenging task for pharmaceutical scientists.
Due to the various anatomical barriers and the clearance mechanisms prevailing in the eye …

The potential of using biodegradable microspheres in retinal diseases and other intraocular pathologies

R Herrero-Vanrell, I Bravo-Osuna… - Progress in retinal and …, 2014 - Elsevier
Pathologies affecting the posterior segment of the eye are one of the major causes of
blindness in developed countries and are becoming more prevalent due to the increase in …

Nanotechnology for medical and surgical glaucoma therapy—a review

ML Occhiutto, RC Maranhão, VP Costa, AG Konstas - Advances in therapy, 2020 - Springer
Glaucoma is the second leading cause of blindness worldwide. Even though significant
advances have been made in its management, currently available antiglaucoma therapies …

Use of poly lactic-co-glycolic acid nano and micro particles in the delivery of drugs modulating different phases of inflammation

C Puricelli, CL Gigliotti, I Stoppa, S Sacchetti… - Pharmaceutics, 2023 - mdpi.com
Chronic inflammation contributes to the pathogenesis of many diseases, including
apparently unrelated conditions such as metabolic disorders, cardiovascular diseases …

Transscleral delivery of dexamethasone-loaded microparticles using a dissolving microneedle array

R Fitaihi, S Abukhamees, M Orlu, DQM Craig - Pharmaceutics, 2023 - mdpi.com
Microneedles (MNs) have attracted considerable interest as a means of ocular drug delivery,
a challenging delivery route due to the limitations imposed by the various biological barriers …

[HTML][HTML] Biodegradable microspheres come into sight: A promising biomaterial for delivering drug to the posterior segment of the eyeball

R Xue, H Wu, S Li, N Pu, D Wei, N Zhao, Y Cui, H Li… - Materials Today Bio, 2024 - Elsevier
Posterior segment disease acts as a major cause of irreversible visual impairments.
Successful treatment of posterior segment disease requires the efficient delivery of …