RNA splicing dysregulation and the hallmarks of cancer
Dysregulated RNA splicing is a molecular feature that characterizes almost all tumour types.
Cancer-associated splicing alterations arise from both recurrent mutations and altered …
Cancer-associated splicing alterations arise from both recurrent mutations and altered …
Protein synthesis control in cancer: selectivity and therapeutic targeting
Translational control of mRNAs is a point of convergence for many oncogenic signals
through which cancer cells tune protein expression in tumorigenesis. Cancer cells rely on …
through which cancer cells tune protein expression in tumorigenesis. Cancer cells rely on …
[HTML][HTML] m6A-driven SF3B1 translation control steers splicing to direct genome integrity and leukemogenesis
SF3B1 is the most mutated splicing factor (SF) in myelodysplastic syndromes (MDSs), which
are clonal hematopoietic disorders with variable risk of leukemic transformation. Although …
are clonal hematopoietic disorders with variable risk of leukemic transformation. Although …
METTL3 regulates breast cancer-associated alternative splicing switches
Alternative splicing (AS) enables differential inclusion of exons from a given transcript,
thereby contributing to the transcriptome and proteome diversity. Aberrant AS patterns play …
thereby contributing to the transcriptome and proteome diversity. Aberrant AS patterns play …
CircSCAP interacts with SF3A3 to inhibit the malignance of non-small cell lung cancer by activating p53 signaling
D Chen, H Zhou, Z Cai, K Cai, J Liu, W Wang… - Journal of Experimental …, 2022 - Springer
Abstract Background Circular RNA (circRNA) has been recently identified as a critical
regulator during carcinogenesis. However, the biological function and potential underlying …
regulator during carcinogenesis. However, the biological function and potential underlying …
Targeting SNRNP200-induced splicing dysregulation offers an immunotherapy opportunity for glycolytic triple-negative breast cancer
W Yang, L Hong, L Guo, Y Wang, X Han, B Han, Z **ng… - Cell Discovery, 2024 - nature.com
Metabolic dysregulation is prominent in triple-negative breast cancer (TNBC), yet
therapeutic strategies targeting cancer metabolism are limited. Here, utilizing multiomics …
therapeutic strategies targeting cancer metabolism are limited. Here, utilizing multiomics …
MYC regulates a pan-cancer network of co-expressed oncogenic splicing factors
L Urbanski, M Brugiolo, SH Park, BL Angarola… - Cell reports, 2022 - cell.com
MYC is dysregulated in> 50% of cancers, but direct targeting of MYC has been clinically
unsuccessful. Targeting downstream MYC effector pathways represents an attractive …
unsuccessful. Targeting downstream MYC effector pathways represents an attractive …
TDP43 promotes stemness of breast cancer stem cells through CD44 variant splicing isoforms
L Guo, H Ke, H Zhang, L Zou, Q Yang, X Lu… - Cell death & …, 2022 - nature.com
Alternative splicing (AS) is a promising clinical target for cancer treatment at the post-
transcriptional level. We previously identified a unique AS profile in triple-negative breast …
transcriptional level. We previously identified a unique AS profile in triple-negative breast …
Bento: a toolkit for subcellular analysis of spatial transcriptomics data
The spatial organization of molecules in a cell is essential for their functions. While current
methods focus on discerning tissue architecture, cell–cell interactions, and spatial …
methods focus on discerning tissue architecture, cell–cell interactions, and spatial …
In-depth analysis of alternative splicing landscape in multiple myeloma and potential role of dysregulated splicing factors
Splicing changes are common in cancer and are associated with dysregulated splicing
factors. Here, we analyzed RNA-seq data from 323 newly diagnosed multiple myeloma …
factors. Here, we analyzed RNA-seq data from 323 newly diagnosed multiple myeloma …