Benefits and harms of hepatocellular carcinoma screening outreach in patients with cirrhosis: a multicenter randomized clinical trial

AG Singal, D Daher, M Narasimman… - JNCI: Journal of the …, 2025 - academic.oup.com
Background The value of hepatocellular carcinoma screening is defined by the balance of
benefits from early tumor detection vs harms because of false-positive results. We evaluated …

Persisting challenges in the early detection of hepatocellular carcinoma

A Arvind, K Redmon, AG Singal - Expert Review of Anticancer …, 2025 - Taylor & Francis
Introduction Prognosis in patients with HCC is largely determined by stage at diagnosis,
highlighting the importance of effective early detection strategies. HCC surveillance is …

Value of HCC surveillance in a landscape of emerging surveillance options: Perspectives of a multi-stakeholder modified delphi panel

AG Singal, L Quirk, J Boike, V Chernyak, Z Feng… - Hepatology, 2024 - journals.lww.com
Hepatocellular carcinoma (HCC) surveillance is recommended by liver professional
societies but lacks broad acceptance by several primary care and cancer societies due to …

[HTML][HTML] Cost-effectiveness of an outreach program for HCC screening in patients with cirrhosis: a microsimulation modeling study

T Gurley, R Hernaez, V Cerda, T Thomas… - …, 2025 - thelancet.com
Background Patients with cirrhosis are at high risk for hepatocellular carcinoma (HCC), but
few undergo guideline-recommended semi-annual screening. Randomized clinical trials …

Mortality of gastrointestinal cancers attributable to smoking, alcohol, and metabolic risk factors, and its association with socioeconomic development status 2000–2021 …

P Danpanichkul, K Suparan, Y Pang… - The American Journal of …, 2025 - Elsevier
Objective Gastrointestinal (GI) cancers account for one-third of global cancer mortality, with
nearly half being preventable. This study updates the global burden of GI cancers attributed …

Is mailed outreach and patient navigation a perfect solution to improve HCC screening?

IP Radu - Gut, 2024 - gut.bmj.com
Hepatocellular carcinoma (HCC) is a significant global health problem, and its incidence is
expected to exceed 1 million new HCC annually by 2025. 1 The reported 3-year survival …