Human tissues express cannabinoid CB1 and CB2 receptors that can be activated by
endogenously released 'endocannabinoids' or exogenously administered compounds in a …

Chronic pain is an important health and social problem. Misuse and abuse of opioids in
chronic non-cancer pain management seem to be a huge problem, in some countries. This …

The effects of Nigella sativa oil on morphine-induced tolerance and dependence in mice
and possible mechanism (s) of these effects were investigated, for the first time, in this study …

Cannabinoid and opioid agonists can display overlap** behavioral effects and the
combination of these agonists is known to produce enhanced antinociception in several …

The endogenous opioid and cannabinoid receptor systems are widely distributed and co-
localized throughout central and peripheral nervous system regions. A large body of …

Background and Purpose Cannabidiol (CBD) is a non‐euphorigenic component of
Cannabis sativa that prevents the development of paclitaxel‐induced mechanical sensitivity …

In spite of the potency and efficacy of morphine, its clinical application for chronic persistent
pain is limited by the development of tolerance to the antinociceptive effect. The cellular and …

Acutely, non-selective cannabinoid (CB) agonists have been shown to increase morphine
antinociceptive effects, and we and others have also demonstrated that non-selective CB …

Pain remains a global health challenge. For decades, clinicians have been primarily relying
on μ-opioid receptor (MOR) agonists and nonsteroidal anti-inflammatory drugs (NSAIDs) for …