Omicron: what makes the latest SARS-CoV-2 variant of concern so concerning?
Emerging strains of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the
causative agent of the coronavirus disease 2019 (COVID-19) pandemic, that show …
causative agent of the coronavirus disease 2019 (COVID-19) pandemic, that show …
Approved antiviral drugs over the past 50 years
E De Clercq, G Li - Clinical microbiology reviews, 2016 - Am Soc Microbiol
Since the first antiviral drug, idoxuridine, was approved in 1963, 90 antiviral drugs
categorized into 13 functional groups have been formally approved for the treatment of the …
categorized into 13 functional groups have been formally approved for the treatment of the …
[HTML][HTML] The paradox of HIV blood–brain barrier penetrance and antiretroviral drug delivery deficiencies
HIV attacks the body's immune cells, frequently compromises the integrity of the blood–brain
barrier (BBB), and infects the CNS in the early stages of infection. Dysfunction of the BBB …
barrier (BBB), and infects the CNS in the early stages of infection. Dysfunction of the BBB …
[HTML][HTML] Approved HIV reverse transcriptase inhibitors in the past decade
G Li, Y Wang, E De Clercq - Acta Pharmaceutica Sinica B, 2022 - Elsevier
HIV reverse transcriptase (RT) inhibitors are the important components of highly active
antiretroviral therapies (HAARTs) for anti-HIV treatment and pre-exposure prophylaxis in …
antiretroviral therapies (HAARTs) for anti-HIV treatment and pre-exposure prophylaxis in …
Population genomics of intrapatient HIV-1 evolution
F Zanini, J Brodin, L Thebo, C Lanz, G Bratt, J Albert… - Elife, 2015 - elifesciences.org
Many microbial populations rapidly adapt to changing environments with multiple variants
competing for survival. To quantify such complex evolutionary dynamics in vivo, time …
competing for survival. To quantify such complex evolutionary dynamics in vivo, time …
HIV genome-wide protein associations: a review of 30 years of research
G Li, E De Clercq - Microbiology and Molecular Biology Reviews, 2016 - Am Soc Microbiol
The HIV genome encodes a small number of viral proteins (ie, 16), invariably establishing
cooperative associations among HIV proteins and between HIV and host proteins, to invade …
cooperative associations among HIV proteins and between HIV and host proteins, to invade …
Current and emerging non-nucleoside reverse transcriptase inhibitors (NNRTIs) for HIV-1 treatment
Y Wang, E De Clercq, G Li - Expert opinion on drug metabolism & …, 2019 - Taylor & Francis
Introduction: Non-nucleoside reverse transcriptase inhibitors (NNRTIs) are essential
components of highly active antiretroviral therapy against HIV-1 infections. Here, we provide …
components of highly active antiretroviral therapy against HIV-1 infections. Here, we provide …
[HTML][HTML] Potent in vitro antiviral activity of Cistus incanus extract against HIV and Filoviruses targets viral envelope proteins
S Rebensburg, M Helfer, M Schneider… - Scientific reports, 2016 - nature.com
Novel therapeutic options are urgently needed to improve global treatment of virus
infections. Herbal products with confirmed clinical safety features are attractive starting …
infections. Herbal products with confirmed clinical safety features are attractive starting …
In vivo mutation rates and the landscape of fitness costs of HIV-1
Mutation rates and fitness costs of deleterious mutations are difficult to measure in vivo but
essential for a quantitative understanding of evolution. Using whole genome deep …
essential for a quantitative understanding of evolution. Using whole genome deep …
HIV-1 protease, reverse transcriptase, and integrase variation
ABSTRACT HIV-1 protease (PR), reverse transcriptase (RT), and integrase (IN) variability
presents a challenge to laboratories performing genotypic resistance testing. This challenge …
presents a challenge to laboratories performing genotypic resistance testing. This challenge …