Cancer cells frequently display fundamentally altered cellular metabolism, which provides
the biochemical foundation and directly contributes to tumorigenicity and malignancy …

Clearance or control of pathogens or tumors usually requires T‐cell‐mediated immunity. As
such, understanding the mechanisms that govern the function, maintenance, and …

CD8+ T cells undergo major metabolic changes upon activation, but how metabolism
influences the establishment of long-lived memory T cells after infection remains a key …

High-throughput targeted lipid profiling with liquid chromatography-mass spectrometry (LC-
MS) has been used extensively to identify associations between plasma lipid species and …

A characteristic of memory T (TM) cells is their ability to mount faster and stronger responses
to reinfection than naïve T (TN) cells do in response to an initial infection. However, the …

Normal energy metabolism is characterized by periodic shifts in glucose and fat oxidation,
as the mitochondrial machinery responsible for carbon combustion switches freely between …

Inefficient muscle long-chain fatty acid (LCFA) combustion is associated with insulin
resistance, but molecular links between mitochondrial fat catabolism and insulin action …

Coenzyme A (CoA) is a ubiquitous essential cofactor that plays a central role in the
metabolism of carboxylic acids, including short-and long-chain fatty acids. In the last few …

Tumor cells gain a survival/growth advantage by adapting their metabolism to respond to
environmental stress, a process known as metabolic transformation. The best-known aspect …

Acetate is a major end product of bacterial fermentation of fiber in the gut. Acetate, whether
derived from the diet or from fermentation in the colon, has been implicated in a range of …