Dendrimer toxicity: Let's meet the challenge
Dendrimers are well-defined, versatile polymeric architecture with properties resembling
biomolecules. Dendritic polymers emerged as outstanding carrier in modern medicine …
biomolecules. Dendritic polymers emerged as outstanding carrier in modern medicine …
Cathepsin-sensitive nanoscale drug delivery systems for cancer therapy and other diseases
Cathepsins are an important category of enzymes that have attracted great attention for the
delivery of drugs to improve the therapeutic outcome of a broad range of nanoscale drug …
delivery of drugs to improve the therapeutic outcome of a broad range of nanoscale drug …
Metal–organic frameworks vs. buffers: case study of UiO-66 stability
D Bůžek, S Adamec, K Lang, J Demel - Inorganic Chemistry Frontiers, 2021 - pubs.rsc.org
UiO-66 is a zirconium-based metal–organic framework (MOF) that has numerous
applications. Our group recently determined that UiO-66 is not as inert in aqueous …
applications. Our group recently determined that UiO-66 is not as inert in aqueous …
Cellular internalization and inhibition capacity of new anti-glioma peptide conjugates: physicochemical characterization and evaluation on various monolayer-and 3D …
Most therapeutic agents used for treating brain malignancies face hindered transport
through the blood–brain barrier (BBB) and poor tissue penetration. To overcome these …
through the blood–brain barrier (BBB) and poor tissue penetration. To overcome these …
The rational design of a gemcitabine prodrug with AIE-based intracellular light-up characteristics for selective suppression of pancreatic cancer cells
An enzyme and reduction-activatable gemcitabine prodrug (TPE-GEM-RGD) with
aggregation-induced emission (AIE) properties was designed for targeted and image …
aggregation-induced emission (AIE) properties was designed for targeted and image …
In vitro degradation and antitumor activity of oxime bond-linked daunorubicin–GnRH-III bioconjugates and DNA-binding properties of daunorubicin–amino acid …
Bioconjugates with receptor-mediated tumor-targeting functions and carrying cytotoxic
agents should enable the specific delivery of chemotherapeutics to malignant tissues, thus …
agents should enable the specific delivery of chemotherapeutics to malignant tissues, thus …
Receptor-mediated tumor targeting based on peptide hormones
G Mező, M Manea - Expert opinion on drug delivery, 2010 - Taylor & Francis
Importance of the field: Tumor targeting with peptides is based on the discovery that
receptors for many regulatory peptides are overexpressed in tumor cells, compared with …
receptors for many regulatory peptides are overexpressed in tumor cells, compared with …
Penetrant competition and plasticization in membranes: How negatives can be positives in natural gas sweetening
Membranes are attractive for upgrading natural gas; however, the gas permeation
processes through membranes are challenging to control. The coexistence of condensable …
processes through membranes are challenging to control. The coexistence of condensable …
Nanomedicine-based formulations containing ω-3 polyunsaturated fatty acids: Potential application in cardiovascular and neoplastic diseases
Omega-3 polyunsaturated fatty acids (ω-3 PUFAs) are dietary factors involved in the
prevention of cardiovascular, inflammatory, and neoplastic diseases. A multidisciplinary …
prevention of cardiovascular, inflammatory, and neoplastic diseases. A multidisciplinary …
Development of an oxime bond containing daunorubicin-gonadotropin-releasing hormone-III conjugate as a potential anticancer drug
I Szabó, M Manea, E Orbán, A Csámpai… - Bioconjugate …, 2009 - ACS Publications
Here, we report on the synthesis and biological properties of a conjugate in which
daunorubicin (Dau) as chemotherapeutic agent was attached through an oxime bond to …
daunorubicin (Dau) as chemotherapeutic agent was attached through an oxime bond to …