Many experimental testing techniques have been adopted in order to provide an
understanding of the biomechanics of the human intervertebral disc (IVD). The aim of this …

BACKGROUND CONTEXT: Degeneration and injuries of the intervertebral disc (IVD) result
in large alterations in biomechanical behaviors. Repair strategies using biomaterials can be …

A comprehensive understanding of the cellular heterogeneity and molecular mechanisms
underlying the development, homeostasis, and disease of human intervertebral disks (IVDs) …

Painful degeneration of soft tissues accounts for high socioeconomic costs. Tissue
engineering aims to provide biomimetics recapitulating native tissues. Biocompatible …

Due to the inability of current clinical practices to restore function to degenerated
intervertebral discs, the arena of disc tissue engineering has received substantial attention …

Study Design. Experimental measurement and normalization of in vitro disc axial
compression mechanics and glycosaminoglycan and water content for several animal …

Hydrogels prepared from poly-(ethylene glycol)(PEG) have been used in a variety of studies
of cartilage tissue engineering. Such hydrogels may also be useful as a tunable mechanical …

The intervertebral disk has a composite structure consisting of a gelatinous proteoglycan-
rich nucleus pulposus surrounded by a collagen-rich anulus fibrosus. The proteoglycan in …

Purpose Degeneration of the intervertebral disc is associated with various morphological
changes of the disc itself and of the adjacent structures, such as reduction of the water …

Surgical treatment for lower back pain related to degenerative disc disease commonly
includes discectomy and spinal fusion. While surgical intervention may provide short-term …