The genus Mycobacterium contains several slow-growing human pathogens, including
Mycobacterium tuberculosis, Mycobacterium leprae, and Mycobacterium avium …

CRISPR interference (CRISPRi) and CRISPR activation (CRISPRa) have become
ubiquitous approaches to control gene expression in bacteria due to their simple design and …

Mycobacteriophages show promise as therapeutic agents for non-tuberculous
mycobacterium infections. However, little is known about phage recognition of …

Transcriptional regulation is a critical adaptive mechanism that allows bacteria to respond to
changing environments, yet the concept of transcriptional plasticity (TP)–the variability of …

Although prokaryotic organisms lack traditional organelles, they must still organize cellular
structures in space and time, challenges that different species solve differently. To …

The intracellular membrane domain (IMD) is a laterally discrete region of the mycobacterial
plasma membrane, enriched in the subpolar region of the rod-shaped cell. Here, we report …

Mycobacterium smegmatis (M. sm) is frequently used as an alternative model organism in
Mycobacterium tuberculosis (M. tb) studies. While containing high sequence homology with …

Abstract The Many Hosts of Mycobacteria (MHM) meeting series brings together basic
scientists, clinicians and veterinarians to promote robust discussion and dissemination of …

The growth and division of mycobacteria, which include clinically relevant pathogens,
deviate from that of canonical bacterial models. Despite their Gram-positive ancestry …

Proteolysis-targeting chimeras (PROTACs) represent a new therapeutic modality involving
selectively directing disease-causing proteins for degradation through proteolytic systems …