B cells are a major component of the tumour microenvironment, where they are
predominantly associated with tertiary lymphoid structures (TLS). In germinal centres within …

The tumor microenvironment (TME) is a heterogeneous, complex organization composed of
tumor, stroma, and endothelial cells that is characterized by cross talk between tumor and …

Abstract Treatment with immune checkpoint blockade (ICB) has revolutionized cancer
therapy. Until now, predictive biomarkers,,,,,,,,–and strategies to augment clinical response …

Simple Summary The relationship between the immune system and tumours is currently one
of the most studied topics in the field of cancer. Previously, it was thought that a tumour could …

Whereas T cells have been considered the major immune cells of the tumor
microenvironment able to induce tumor regression and control cancer clinical outcome, a …

This study identifies mechanisms mediating responses to immune checkpoint inhibitors
using mouse models of triple-negative breast cancer. By creating new mammary tumor …

Metastatic melanoma is among the most enigmatic advanced cancers to clinically manage
despite immense progress in the way of available therapeutic options and historic …

PURPOSE CALGB 40603 (NCT00861705), a 2× 2 randomized phase II trial, demonstrated
that adding carboplatin or bevacizumab to weekly paclitaxel (wP) followed by doxorubicin …

Abstract RNA-sequencing (RNA-seq) has become an increasingly cost-effective technique
for molecular profiling and immune characterization of tumors. In the past decade, many …

Background: Melanoma is highly immunogenic and therefore suitable for immunotherapy,
but the efficacy is limited by response rate. In several types of tumor, tumor mutation burden …