The heart is uniquely responsible for providing its own blood supply through the coronary
circulation. Regulation of coronary blood flow is quite complex and, after over 100 years of …

Exercise is the most important physiological stimulus for increased myocardial oxygen
demand. The requirement of exercising muscle for increased blood flow necessitates an …

The vascular myogenic response refers to the acute reaction of a blood vessel to a change
in transmural pressure. This response is critically important for the development of resting …

CLINICAL BLEEDING or thrombosis results from a disturbance in the balance between a
complex network of procoagulant and anticoagulant factors. This network involves three …

The regulation of blood flow has rich history of investigation and is exemplified in exercising
skeletal muscle by a concerted interaction between striated muscle fibers and their …

Blood flow (BF) increases with increasing exercise intensity in skeletal, respiratory, and
cardiac muscle. In humans during maximal exercise intensities, 85% to 90% of total cardiac …

Abstract Small arterioles (40–150 μm) contribute to the majority of vascular resistance within
organs and tissues. Under resting conditions, the basal tone of these vessels is determined …

Flow-induced dilation (FID) is dependent largely on hyperpolarization of vascular smooth
muscle cells (VSMCs) in human coronary arterioles (HCA) from patients with coronary …

In recent decades, it has become evident that the endothelium is by no means a passive
inner lining of blood vessels. This 'organ'with a large surface (∼ 350 m 2) and a …

Flow-induced changes in vessel caliber tend to restore baseline wall shear stress (WSS)
and have been reported to be endothelium-dependent. To investigate the role of …