Turnitin
降AI改写
早检测系统
早降重系统
Turnitin-UK版
万方检测-期刊版
维普编辑部版
Grammarly检测
Paperpass检测
checkpass检测
PaperYY检测
Hepatic cholesterol transport and its role in non-alcoholic fatty liver disease and atherosclerosis
H Li, XH Yu, X Ou, XP Ouyang, CK Tang - Progress in lipid research, 2021 - Elsevier
Non-alcoholic fatty liver disease (NAFLD) is a quickly emerging global health problem
representing the most common chronic liver disease in the world. Atherosclerotic …
representing the most common chronic liver disease in the world. Atherosclerotic …
Acyl-coenzyme A: cholesterol acyltransferases
The enzymes acyl-coenzyme A (CoA): cholesterol acyltransferases (ACATs) are membrane-
bound proteins that utilize long-chain fatty acyl-CoA and cholesterol as substrates to form …
bound proteins that utilize long-chain fatty acyl-CoA and cholesterol as substrates to form …
Fungal natural products in research and development
A Schueffler, T Anke - Natural product reports, 2014 - pubs.rsc.org
Covering: 2009 to 2013 To date approximately 100 000 fungal species are known although
far more than one million are expected. The variety of species and the diversity of their …
far more than one million are expected. The variety of species and the diversity of their …
Reconstitution of a fungal meroterpenoid biosynthesis reveals the involvement of a novel family of terpene cyclases
Meroterpenoids are hybrid natural products of both terpenoid and polyketide origin. We
identified a biosynthetic gene cluster that is responsible for the production of the …
identified a biosynthetic gene cluster that is responsible for the production of the …
Structural insights into the inhibition mechanism of human sterol O-acyltransferase 1 by a competitive inhibitor
Abstract Sterol O-acyltransferase 1 (SOAT1) is an endoplasmic reticulum (ER) resident, multi-
transmembrane enzyme that belongs to the membrane-bound O-acyltransferase (MBOAT) …
transmembrane enzyme that belongs to the membrane-bound O-acyltransferase (MBOAT) …
Chemistry of fungal meroterpenoid cyclases
Covering: up to July 2020 Fungal meroterpenoid cyclases are a recently discovered
emerging family of membrane-integrated, non-canonical terpene cyclases. They catalyze …
emerging family of membrane-integrated, non-canonical terpene cyclases. They catalyze …
Targeting Sterol O-Acyltransferase/Acyl-CoA:Cholesterol Acyltransferase (ACAT): A Perspective on Small-Molecule Inhibitors and Their Therapeutic Potential
Sterol O-acyltransferase (SOAT) is a membrane-bound enzyme that aids the esterification of
cholesterol and fatty acids to cholesterol esters. SOAT has been studied extensively as a …
cholesterol and fatty acids to cholesterol esters. SOAT has been studied extensively as a …
Exploiting the potential of meroterpenoid cyclases to expand the chemical space of fungal meroterpenoids
T Mitsuhashi, L Barra, Z Powers… - Angewandte Chemie …, 2020 - Wiley Online Library
Fungal meroterpenoids are a diverse group of hybrid natural products with impressive
structural complexity and high potential as drug candidates. In this work, we evaluate the …
structural complexity and high potential as drug candidates. In this work, we evaluate the …
Molecular structures of human ACAT2 disclose mechanism for selective inhibition
Endoplasmic reticulum-localized acyl-CoA: cholesterol acyltransferases (ACAT), including
ACAT1 and ACAT2, convert cholesterol to cholesteryl esters that become incorporated into …
ACAT1 and ACAT2, convert cholesterol to cholesteryl esters that become incorporated into …
Pyripyropene a, an acyl–coenzyme a: cholesterol acyltransferase 2–selective inhibitor, attenuates hypercholesterolemia and atherosclerosis in murine models of …
T Ohshiro, D Matsuda, K Sakai… - … , and vascular biology, 2011 - ahajournals.org
Objective—Pyripyropene A (PPPA) of fungal origin is the first compound that has been found
to strongly and selectively inhibit acyl–coenzyme A: cholesterol acyltransferase 2 (ACAT2) …
to strongly and selectively inhibit acyl–coenzyme A: cholesterol acyltransferase 2 (ACAT2) …