Rising interest in the mechanism and function of the proteasomes and the ubiquitin system
revealed that it is hard to find any aspect of the cellular metabolic network that is not directly …

The coordinated activities of innate and adaptive immunity are critical for effective protection
against viruses. To counter this, some viruses have evolved sophisticated strategies to …

Cancer is one of the leading causes of death worldwide. Human cytomegalovirus (HCMV), a
well-studied herpesvirus, has been implicated in malignancies derived from breast …

Major mechanisms for the recognition of pathogens by immune cells have evolved to
employ classical and non-classical major histocompatibility complex class I (MHC I) …

Human cytomegalovirus (HCMV) represents a prototypic pathogenic member of the β‐
subgroup of the herpesvirus family. A range of HCMV features like its lytic replication in …

Human cytomegalovirus (HCMV) is ubiquitously prevalent. HCMV infection is typically
asymptomatic and controlled by the immune system in healthy individuals, yet HCMV can be …

Members of the Herpesviridae family have the capacity to undergo both lytic and latent
infection to establish a lifelong relationship with their host. Following primary infection …

Natural killer (NK) cells play an important role in the host response against viral infections
and cancer development. They are able to kill virus-infected and tumor cells, and they …

No one likes to feel like they have been manipulated, but in the case of cytomegalovirus
(CMV) immune manipulation, we do not really have much choice. Whether you call it CMV …

Abstract Human CMV (HCMV)-encoded NK cell-evasion functions include an MHC class I
homolog (UL18) with high affinity for the leukocyte inhibitory receptor-1 (CD85j, ILT2, or …