Fragrance skin sensitization evaluation and human testing: 30-year experience
M Na, G Ritacco, D O'Brien, M Lavelle, AM Api… - Dermatitis, 2021 - liebertpub.com
Background The human repeated insult patch test (HRIPT) has a history of use in the
fragrance industry as a component of safety evaluation, exclusively to confirm the absence …
fragrance industry as a component of safety evaluation, exclusively to confirm the absence …
Production, properties, and applications of α-terpineol
Abstract α-Terpineol (CAS No. 98-55-5) is a tertiary monoterpenoid alcohol widely and
commonly used in the flavors and fragrances industry for its sensory properties. It is present …
commonly used in the flavors and fragrances industry for its sensory properties. It is present …
Integrating habits and practices data for soaps, cosmetics and air care products into an existing aggregate exposure model
D Comiskey, AM Api, C Barrett, G Ellis… - Regulatory Toxicology …, 2017 - Elsevier
In order to accurately assess aggregate exposure to a fragrance material in consumers, data
are needed on consumer habits and practices, as well as the concentration of the fragrance …
are needed on consumer habits and practices, as well as the concentration of the fragrance …
Application of the expanded Creme RIFM consumer exposure model to fragrance ingredients in cosmetic, personal care and air care products
B Safford, AM Api, C Barratt, D Comiskey, G Ellis… - Regulatory Toxicology …, 2017 - Elsevier
As part of a joint project between the Research Institute for Fragrance Materials (RIFM) and
Creme Global, a Monte Carlo model (here named the Creme RIFM model) has been …
Creme Global, a Monte Carlo model (here named the Creme RIFM model) has been …
The BlueScreen HC assay to predict the genotoxic potential of fragrance materials
BlueScreen HC is a mammalian cell-based assay for measuring the genotoxicity and
cytotoxicity of chemical compounds and mixtures. The BlueScreen HC assay has been …
cytotoxicity of chemical compounds and mixtures. The BlueScreen HC assay has been …
Clustering a chemical inventory for safety assessment of fragrance ingredients: identifying read-across analogs to address data gaps
MS Date, D O'Brien, DJ Botelho… - Chemical research in …, 2020 - ACS Publications
A valuable approach to chemical safety assessment is the use of read-across chemicals to
provide safety data to support the assessment of structurally similar chemicals. An inventory …
provide safety data to support the assessment of structurally similar chemicals. An inventory …
Do synthetic fragrances in personal care and household products impact indoor air quality and pose health risks?
G Rádis-Baptista - Journal of xenobiotics, 2023 - mdpi.com
Fragrance compounds (synthetic fragrances or natural essential oils) comprise formulations
of specific combinations of individual materials or mixtures. Natural or synthetic scents are …
of specific combinations of individual materials or mixtures. Natural or synthetic scents are …
[HTML][HTML] Updating exposure assessment for skin sensitization quantitative risk assessment for fragrance materials
AM Api, D Basketter, J Bridges, P Cadby, G Ellis… - Regulatory Toxicology …, 2020 - Elsevier
In 2008, a proposal for assessing the risk of induction of skin sensitization to fragrance
materials Quantitative Risk Assessment 1 (QRA1) was published. This was implemented for …
materials Quantitative Risk Assessment 1 (QRA1) was published. This was implemented for …
[HTML][HTML] T4 report: Toward good read-across practice (GRAP) guidance
N Ball, MTD Cronin, J Shen, K Blackburn, ED Booth… - Altex, 2016 - ncbi.nlm.nih.gov
Grou** of substances and utilizing read-across of data within those groups represents an
important data gap filling technique for chemical safety assessments. Categories/analogue …
important data gap filling technique for chemical safety assessments. Categories/analogue …
[HTML][HTML] Internationalization of read-across as a validated new approach method (NAM) for regulatory toxicology
Read-across (RAx) translates available information from well-characterized chemicals to a
substance for which there is a toxicological data gap. The OECD is working on case studies …
substance for which there is a toxicological data gap. The OECD is working on case studies …