Discovery of novel benzenesulfonamides incorporating 1, 2, 3-triazole scaffold as carbonic anhydrase I, II, IX, and XII inhibitors
Sulfonamides are among the most promising potential inhibitors for carbonic anhydrases
(CAs), which are pharmaceutically relevant targets for treating several disease conditions …
(CAs), which are pharmaceutically relevant targets for treating several disease conditions …
Cytotoxic effect, enzyme inhibition, and in silico studies of some novel N-substituted sulfonyl amides incorporating 1,3,4-oxadiazol structural motif
The acetylcholinesterase and carbonic anhydrase inhibitors (AChEIs and h CAIs) remain
key therapeutic agents for many bioactivities such as anti-Alzheimer and antiobesity …
key therapeutic agents for many bioactivities such as anti-Alzheimer and antiobesity …
Recent advances in research of colchicine binding site inhibitors and their interaction modes with tubulin
K Sun, Z Sun, F Zhao, G Shan… - Future Medicinal Chemistry, 2021 - Taylor & Francis
Microtubules have been a concerning target of cancer chemotherapeutics for decades, and
several tubulin-targeted agents, such as paclitaxel, vincristine and vinorelbine, have been …
several tubulin-targeted agents, such as paclitaxel, vincristine and vinorelbine, have been …
Mechanistic insights and docking studies of phytomolecules as potential candidates in the management of cancer
Background: Cancer is a leading risk of death globally. According to the World Health
Organization, it is presently the second most important disease that causes death in both …
Organization, it is presently the second most important disease that causes death in both …
[HTML][HTML] The Remarkable and Selective In Vitro Cytotoxicity of Synthesized Bola-Amphiphilic Nanovesicles on Etoposide-Sensitive and-Resistant Neuroblastoma …
S Alfei, P Giannoni, MG Signorello, C Torazza… - Nanomaterials, 2024 - mdpi.com
Neuroblastoma (NB) is a solid tumor occurring in infancy and childhood. Its high-risk form
has currently a survival rate< 50%, despite aggressive treatments. This worrying scenario is …
has currently a survival rate< 50%, despite aggressive treatments. This worrying scenario is …
Haloarchaeal carotenoids exert an in vitro antiproliferative effect on human breast cancer cell lines
Oxidative stress has been linked to the onset and progression of different neoplasia.
Antioxidants might help prevent it by modulating biochemical processes involved in cell …
Antioxidants might help prevent it by modulating biochemical processes involved in cell …
A Lipophilic Salt Form to Enhance the Lipid Solubility and Certain Biopharmaceutical Properties of Lapatinib
Lapatinib (LTP) commercially available as lapatinib ditosylate (LTP-DTS) salt is the only
drug approved for the treatment of HER-positive metastatic breast cancer. A low and pH …
drug approved for the treatment of HER-positive metastatic breast cancer. A low and pH …
Synthesis and Biological Evaluation of Colchicine─ Aryl/Alkyl Amine Hybrids as Potential Noncytotoxic Cholinesterase Inhibitors: Identification of SBN-284 as a Dual …
Colchicine, one of the oldest anti-inflammatory natural products still used clinically, inhibits
NF-κB signaling and NLRP3 inflammasome activation. Despite its cytotoxicity and narrow …
NF-κB signaling and NLRP3 inflammasome activation. Despite its cytotoxicity and narrow …
Biochemical and pathophysiological improvements in rats with thioacetamide induced-hepatocellular carcinoma using aspirin plus vitamin C
Background Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related
death, so we should be concerned and look for effective/less-harmful treatments than …
death, so we should be concerned and look for effective/less-harmful treatments than …
Design, synthesis, characterization, and biological activities of novel Ag (I)-NHC complexes based on 1, 3-dioxane ligand
Herein, a series of new Ag (I)-NHC complexes containing 1, 3-dioxane group were
synthesized by the direct reaction of Ag 2 O and benzimidazolium salts in light-free …
synthesized by the direct reaction of Ag 2 O and benzimidazolium salts in light-free …