Heparan sulfate (HS) proteoglycans (PGs) are ubiquitously expressed on cell surfaces and
in the extracellular matrix of most animal tissues, having essential functions in development …

Heparan sulphate proteoglycans reside on the plasma membrane of all animal cells studied
so far and are a major component of extracellular matrices. Studies of model organisms and …

▪ Abstract Virtually every cell type in metazoan organisms produces heparan sulfate. These
complex polysaccharides provide docking sites for numerous protein ligands and receptors …

This paper presents the 12th update of the human obesity gene map, which incorporates
published results up to the end of October 2005. Evidence from single‐gene mutation …

Abstract The melanocortin-4 receptor (MC4R) was cloned in 1993 by degenerate PCR;
however, its function was unknown. Subsequent studies suggest that the MC4R might be …

Appetite is regulated by a complex system of central and peripheral signals which interact in
order to modulate the individual response to nutrient ingestion. Peripheral regulation …

Glycosaminoglycans, linear carbohydrates such as heparan sulfate and hyaluronan,
participate in a variety of biological processes including cell‐matrix interactions and …

The melanocortin system consists of melanocortin peptides derived from the
proopiomelanocortin gene, five melanocortin receptors, two endogenous antagonists, and …

Cellular interactions with the extracellular matrix and with neighboring cells profoundly
influence a variety of signaling events including those involved in mitogenesis, survival, and …

Cell-associated proteoglycans provide highly complex and sophisticated systems to control
interactions of extracellular cell matrix components and soluble ligands with the cell surface …