SARS-CoV-2 infects red blood cell progenitors and dysregulates hemoglobin and iron metabolism

R Kronstein-Wiedemann, M Stadtmüller… - Stem Cell Reviews and …, 2022 - Springer
Background SARS-CoV-2 infection causes acute respiratory distress, which may progress to
multiorgan failure and death. Severe COVID-19 disease is accompanied by reduced …

SARS-CoV-2-associated lymphopenia: possible mechanisms and the role of CD147

S Shouman, N El-Kholy, AE Hussien… - Cell Communication and …, 2024 - Springer
T lymphocytes play a primary role in the adaptive antiviral immunity. Both lymphocytosis and
lymphopenia were found to be associated with severe acute respiratory syndrome …

Metabolomic and immune alterations in long COVID patients with chronic fatigue syndrome

S Saito, S Shahbaz, X Luo, M Osman… - Frontiers in …, 2024 - frontiersin.org
Introduction A group of SARS-CoV-2 infected individuals present lingering symptoms,
defined as long COVID (LC), that may last months or years post the onset of acute disease …

[HTML][HTML] Diverse immunological dysregulation, chronic inflammation, and impaired erythropoiesis in long COVID patients with chronic fatigue syndrome

S Saito, S Shahbaz, M Osman, D Redmond… - Journal of …, 2024 - Elsevier
A substantial number of patients recovering from acute SARS-CoV-2 infection present
serious lingering symptoms, often referred to as long COVID (LC). However, a subset of …

Galectin-9 promotes natural killer cells activity via interaction with CD44

A Rahmati, S Bigam, S Elahi - Frontiers in immunology, 2023 - frontiersin.org
Natural killer (NK) cells are a potent innate source of cytokines and cytoplasmic granules.
Their effector functions are tightly synchronized by the balance between the stimulatory and …

The quality of SARS-CoV-2–specific T cell functions differs in patients with mild/moderate versus severe disease, and T cells expressing coinhibitory receptors are …

S Shahbaz, L Xu, W Sligl, M Osman… - The Journal of …, 2021 - journals.aai.org
Understanding the function of SARS-CoV-2 Ag-specific T cells is crucial for the monitoring of
antiviral immunity and vaccine design. Currently, both impaired and robust T cell immunity is …

[HTML][HTML] The role of CD71+ erythroid cells in the regulation of the immune response

TM Grzywa, D Nowis, J Golab - Pharmacology & therapeutics, 2021 - Elsevier
Complex regulation of the immune response is necessary to support effective defense of an
organism against hostile invaders and to maintain tolerance to harmless microorganisms …

[HTML][HTML] The role of acidosis in the pathogenesis of severe forms of COVID-19

YD Nechipurenko, DA Semyonov, IA Lavrinenko… - Biology, 2021 - mdpi.com
Simple Summary Recently, several studies have shown that acidosis, which is increased
acidity in the blood and other body tissues, is often associated with severe COVID-19. In this …

Analysis of SARS-CoV-2 isolates, namely the Wuhan strain, Delta variant, and Omicron variant, identifies differential immune profiles

S Shahbaz, N Bozorgmehr, J Lu, M Osman… - Microbiology …, 2023 - journals.asm.org
There is an urgent need to better understand the impact of different severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) variants on immune response and disease …

High–temporal resolution profiling reveals distinct immune trajectories following the first and second doses of COVID-19 mRNA vaccines

D Rinchai, S Deola, G Zoppoli, BSA Kabeer… - Science …, 2022 - science.org
Knowledge of the mechanisms underpinning the development of protective immunity
conferred by mRNA vaccines is fragmentary. Here, we investigated responses to …