Retinal bipolar cells are the first'projection neurons' of the vertebrate visual system—all of
the information needed for vision is relayed by this intraretinal connection. Each of the at …

Metabotropic glutamate (mGlu) receptors were discovered in the mid 1980s and originally
described as glutamate receptors coupled to polyphosphoinositide hydrolysis. Almost 6500 …

Transient receptor potential (TRP) channels are a widely expressed family of 28
evolutionarily conserved cationic ion channels that operate as primary detectors of chemical …

In the retina, rod and cone photoreceptors form distinct connections with different classes of
downstream bipolar cells. However, the molecular mechanisms responsible for their …

Neural circuit wiring relies on selective synapse formation whereby a presynaptic release
apparatus is matched with its cognate postsynaptic machinery. At metabotropic synapses …

The extent and temporal characteristics of G protein–coupled receptor (GPCR) signaling are
shaped by the regulator of G protein signaling (RGS) proteins, which promote G protein …

Synapse formation within the retinal circuit ensures that distinct neuronal types can
communicate efficiently to process visual signals. Synapses thus form the core of the visual …

Establishing synaptic contacts between neurons is paramount for nervous system function.
This process involves transsynaptic interactions between a host of cell adhesion molecules …

Synaptic transmission between light-sensory photoreceptor cells and downstream ON-
bipolar neurons plays an important role for vertebrate vision. This process is mediated by the …

Expression of channels to specific neuronal sites can critically impact their function and
regulation. Currently, the molecular mechanisms underlying this targeting and intracellular …