Advances in microfluidic materials, functions, integration, and applications

PN Nge, CI Rogers, AT Woolley - Chemical reviews, 2013 - ACS Publications
Microfluidics consist of microfabricated structures for liquid handling, with cross sections in
the 1–500 μm range and small volume capacity (femtoliter to nanoliter). Capillary tubes …

Engineers are from PDMS-land, Biologists are from Polystyrenia

E Berthier, EWK Young, D Beebe - Lab on a Chip, 2012 - pubs.rsc.org
As the integration of microfluidics into cell biology research proceeds at an ever-increasing
pace, a critical question for those working at the interface of both disciplines is which device …

3D printed microfluidic devices: a review focused on four fundamental manufacturing approaches and implications on the field of healthcare

V Mehta, SN Rath - Bio-Design and Manufacturing, 2021 - Springer
In the last few years, 3D printing has emerged as a promising alternative for the fabrication
of microfluidic devices, overcoming some of the limitations associated with conventional soft …

Fundamentals of microfluidic cell culture in controlled microenvironments

EWK Young, DJ Beebe - Chemical Society Reviews, 2010 - pubs.rsc.org
Microfluidics has the potential to revolutionize the way we approach cell biology research.
The dimensions of microfluidic channels are well suited to the physical scale of biological …

Advances in organ-on-a-chip materials and devices

BK Nahak, A Mishra, S Preetam… - ACS applied bio …, 2022 - ACS Publications
The organ-on-a-chip (OoC) paves a way for biomedical applications ranging from preclinical
to clinical translational precision. The current trends in the in vitro modeling is to reduce the …

Tumour-on-a-chip: microfluidic models of tumour morphology, growth and microenvironment

HF Tsai, A Trubelja, AQ Shen… - Journal of The Royal …, 2017 - royalsocietypublishing.org
Cancer remains one of the leading causes of death, albeit enormous efforts to cure the
disease. To overcome the major challenges in cancer therapy, we need to have a better …

Comparison of biocompatibility and adsorption properties of different plastics for advanced microfluidic cell and tissue culture models

PM van Midwoud, A Janse, MT Merema… - Analytical …, 2012 - ACS Publications
Microfluidic technology is providing new routes toward advanced cell and tissue culture
models to better understand human biology and disease. Many advanced devices have …

Oxygen control: the often overlooked but essential piece to create better in vitro systems

V Palacio-Castañeda, N Velthuijs, S Le Gac… - Lab on a Chip, 2022 - pubs.rsc.org
Variations in oxygen levels play key roles in numerous physiological and pathological
processes, but are often not properly controlled in in vitro models, introducing a significant …

[HTML][HTML] The impact of microfluidics in high-throughput drug-screening applications

P De Stefano, E Bianchi, G Dubini - Biomicrofluidics, 2022 - pubs.aip.org
Drug discovery is an expensive and lengthy process. Among the different phases, drug
discovery and preclinical trials play an important role as only 5–10 of all drugs that begin …

Microfluidic-based 3D engineered microvascular networks and their applications in vascularized microtumor models

X Wang, Q Sun, J Pei - Micromachines, 2018 - mdpi.com
The microvasculature plays a critical role in human physiology and is closely associated to
various human diseases. By combining advanced microfluidic-based techniques, the …