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Interactions between hyaluronan and its receptors (CD44, RHAMM) regulate the activities of inflammation and cancer
S Misra, VC Hascall, RR Markwald… - Frontiers in …, 2015 - frontiersin.org
The glycosaminoglycan hyaluronan (HA), a major component of extracellular matrices, and
cell surface receptors of HA have been proposed to have pivotal roles in cell proliferation …
cell surface receptors of HA have been proposed to have pivotal roles in cell proliferation …
Spheroid culture as a tool for creating 3D complex tissues
3D cell culture methods confer a high degree of clinical and biological relevance to in vitro
models. This is specifically the case with the spheroid culture, where a small aggregate of …
models. This is specifically the case with the spheroid culture, where a small aggregate of …
3D cell culture systems modeling tumor growth determinants in cancer target discovery
Phenotypic heterogeneity of cancer cells, cell biological context, heterotypic crosstalk and
the microenvironment are key determinants of the multistep process of tumor development …
the microenvironment are key determinants of the multistep process of tumor development …
Biomineralization process in hard tissues: The interaction complexity within protein and inorganic counterparts
Biomineralization can be considered as nature's strategy to produce and sustain
biominerals, primarily via creation of hard tissues for protection and support. This review …
biominerals, primarily via creation of hard tissues for protection and support. This review …
CD44/CD44v6 a reliable companion in cancer-initiating cell maintenance and tumor progression
Metastasis is the leading cause of cancer death, tumor progression proceeding through
emigration from the primary tumor, gaining access to the circulation, leaving the circulation …
emigration from the primary tumor, gaining access to the circulation, leaving the circulation …
CD44, hyaluronan, the hematopoietic stem cell, and leukemia-initiating cells
M Zoeller - Frontiers in immunology, 2015 - frontiersin.org
CD44 is an adhesion molecule that varies in size due to glycosylation and insertion of so-
called variant exon products. The CD44 standard isoform (CD44s) is highly expressed in …
called variant exon products. The CD44 standard isoform (CD44s) is highly expressed in …
Journey into bone models: a review
Bone is a complex tissue with a variety of functions, such as providing mechanical stability
for locomotion, protection of the inner organs, mineral homeostasis and haematopoiesis. To …
for locomotion, protection of the inner organs, mineral homeostasis and haematopoiesis. To …
A novel three-dimensional heterotypic spheroid model for the assessment of the activity of cancer immunotherapy agents
S Herter, L Morra, R Schlenker, J Sulcova… - Cancer Immunology …, 2017 - Springer
The complexity of the tumor microenvironment is difficult to mimic in vitro, particularly
regarding tumor–host interactions. To enable better assessment of cancer immunotherapy …
regarding tumor–host interactions. To enable better assessment of cancer immunotherapy …
Hematopoietic stem cell development, niches, and signaling pathways
Hematopoietic stem cells (HSCs) play a key role in hematopoietic system that functions
mainly in homeostasis and immune response. HSCs transplantation has been applied for …
mainly in homeostasis and immune response. HSCs transplantation has been applied for …
A novel model of dormancy for bone metastatic breast cancer cells
Mortality of patients with breast cancer is due overwhelmingly to metastatic spread of the
disease. Although dissemination is an early event in breast cancer, extended periods of …
disease. Although dissemination is an early event in breast cancer, extended periods of …