Little progress has been made in the treatment of gliomas during the past 25 years. One
reason is our poor understanding of the cell of origin in these tumors and of the mechanisms …

In the vertebrate central nervous system, multipotential cells have been identified in vitro and
in vivo. Defined mitogens cause the proliferation of multipotential cells in vitro, the …

Most current research on human brain tumors is focused on the molecular and cellular
analysis of the bulk tumor mass. However, there is overwhelming evidence in some …

Glioblastoma (GBM) is the most frequent and malignant form of primary brain tumor. GBM is
essentially incurable and its resistance to therapy is attributed to a subpopulation of cells …

New neurons are continuously added in specific regions of the adult mammalian central
nervous system. These neurons are derived from multipotent stem cells whose identity has …

Glioblastoma (GBM) is the most malignant brain tumor and is highly resistant to intensive
combination therapies and anti-VEGF therapies. To assess the resistance mechanism to anti …

Neural stem cells from neurogenic regions of mammalian CNS are clonogenic in an in vitro
culture system exploiting serum and anchorage withdrawal in medium supplemented with …

Spinal cord injury often results in permanent functional impairment. Neural stem cells
present in the adult spinal cord can be expanded in vitro and improve recovery when …

In current clinical practice, histology-based grading of diffuse infiltrative gliomas is the best
predictor of patient survival time. Yet histology provides little insight into the underlying …

Most current research on human brain tumors is focused on the molecular and cellular
analysis of the bulk tumor mass. However, evidence in leukemia and more recently in solid …