Intermediate filaments (IFs) are cytoskeletal and nucleoskeletal structures that provide
mechanical and stress-co** resilience to cells, contribute to subcellular and tissue-specific …

Abstract Sirtuin 2 (SIRT2) is an NAD+-dependent deacetylase that was under studied
compared to other sirtuin family members. SIRT2 is the only sirtuin protein which is …

Protein lysine acetylation is an important posttranslational modification that regulates
numerous biological processes. Targeting lysine acetylation regulatory factors, such as …

1.1. Discovery of Sirtuins The founding member of sirtuin is the yeast-silencing information
regulator 2 (SIR2) protein, one of four proteins (SIR1− 4) required for silencing the mating …

Mechanically induced signal transduction has an essential role in development. Cells
actively transduce and respond to mechanical signals and their internal architecture must …

The cytoprotective keratins (K) compose the intermediate filaments of epithelial cells and
their inherited and spontaneous mutations give rise to keratinopathies. For example …

Sirtuins are a highly conserved family of nicotinamide adenine dinucleotide (NAD+)-
dependent protein lysine modifying enzymes with deacetylase, adenosine …

Keratins form the major intermediate filament cytoskeleton of epithelia and are assembled
from heterodimers of 28 type I and 26 type II keratins in cell-and differentiation-dependent …

AKT/PKB kinases transmit insulin and growth factor signals downstream of
phosphatidylinositol 3-kinase (PI3K). AKT activation involves phosphorylation at two …

Impaired hepatic glucose uptake (HGU) causes postprandial hyperglycemia in type 2
diabetes. Here, we show that diminished hepatic Sirt2 activity impairs HGU in obese diabetic …