Although experimental protein-structure determination usually targets known proteins,
chains of unknown sequence are often encountered. They can be purified from natural …

Crimean-Congo hemorrhagic fever virus (CCHFV) is the most widespread tick-borne
zoonotic virus, with a 30% case fatality rate in humans. Structural information is lacking in …

Interactive model building can be a difficult and time-consuming step in the structure-
solution process. Automated model-building programs such as Buccaneer often make it …

In late 2020, the results of CASP14, the 14th event in a series of competitions to assess the
latest developments in computational protein structure-prediction methodology, revealed the …

Advanced glycation end-products (AGE) are a pervasive form of protein damage implicated
in the pathogenesis of neurodegenerative disease, atherosclerosis and diabetes mellitus …

Precise synapse formation is essential for normal functioning of the nervous system. Retinal
photoreceptors establish selective contacts with bipolar cells, aligning the neurotransmitter …

Oral and gut microbiomes are important for the maintenance of homeostasis in the human
body. Altered or disturbed mutualism between their members results in dysbiosis with local …

Ferredoxins are small iron–sulfur proteins and key players in essential metabolic pathways.
Among all types, 3Fe–4S ferredoxins are less studied mostly due to anaerobic requirements …

The analysis of large structural databases reveals general features and relationships among
proteins, providing useful insight. A different approach is required to characterize ubiquitous …

The heme enzyme myeloperoxidase (MPO) is one of the key players in the neutrophil-
mediated killing of invading pathogens as part of the innate immune system. MPO generates …