In response to nitrogen starvation in the presence of a poor carbon source, diploid cells of
the yeast Saccharomyces cerevisiae undergo meiosis and package the haploid nuclei …

The number, length, distribution and polarity of microtubules are largely controlled by
microtubule-organizing centres, which nucleate and anchor microtubule minus ends in a …

The centrosome was discovered in the late 19th century when mitosis was first described.
Long recognized as a key organelle of the spindle pole, its core component, the centriole …

Over the past 100 years, the centrosome has risen in status from an enigmatic organelle,
located at the focus of microtubules, to a key player in cell-cycle progression and cellular …

γ-tubulin exists in two related complexes in Drosophila embryo extracts (Moritz, M., Y.
Zheng, BM Alberts, and K. Oegema. 1998. J. Cell Biol. 142: 1–12). Here, we report the …

▪ Abstract Nucleation of microtubules by eukaryotic microtubule organizing centers (MTOCs)
is required for a variety of functions, including chromosome segregation during mitosis and …

Sporulation of the baker's yeast Saccharomyces cerevisiae is a response to nutrient
depletion that allows a single diploid cell to give rise to four stress-resistant haploid spores …

Microtubules are essential for intracellular organization and chromosome segregation. They
are nucleated by the γ-tubulin ring complex (γTuRC). However, isolated vertebrate γTuRC …

Bfa1p and Bub2p are spindle checkpoint proteins that likely have GTPase activation activity
and are associated with the budding yeast spindle pole body (SPB). Here, we show that …

Microtubule nucleation is the best known function of centrosomes. Centrosomal microtubule
nucleation is mediated primarily by γ tubulin ring complexes (γ TuRCs). However, little is …