Diversity and complexity of cell death: a historical review

W Park, S Wei, BS Kim, B Kim, SJ Bae… - … & molecular medicine, 2023 - nature.com
Death is the inevitable fate of all living organisms, whether at the individual or cellular level.
For a long time, cell death was believed to be an undesirable but unavoidable final outcome …

[HTML][HTML] The role of copper homeostasis in brain disease

Y An, S Li, X Huang, X Chen, H Shan… - International journal of …, 2022 - mdpi.com
In the human body, copper is an important trace element and is a cofactor for several
important enzymes involved in energy production, iron metabolism, neuropeptide activation …

Biofilm microenvironment‐responsive self‐assembly nanoreactors for all‐stage biofilm associated infection through bacterial cuproptosis‐like death and macrophage …

J Mei, D Xu, L Wang, L Kong, Q Liu, Q Li… - Advanced …, 2023 - Wiley Online Library
Bacterial biofilm‐associated infections (BAIs) are the leading cause of prosthetic implant
failure. The dense biofilm structure prevents antibiotic penetration, while the highly acidic …

Photothermally triggered copper payload release for cuproptosis‐promoted cancer synergistic therapy

J Zhou, Q Yu, J Song, S Li, XL Li, B Kang… - Angewandte Chemie …, 2023 - Wiley Online Library
Cuproptosis is a new form of programmed cell death and exhibits enormous potential in
cancer treatment. However, reducing the undesirable Cu ion release in normal tissue and …

Cellular Trojan Horse initiates bimetallic Fe-Cu MOF-mediated synergistic cuproptosis and ferroptosis against malignancies

K Chen, A Zhou, X Zhou, J He, Y Xu, X Ning - Science Advances, 2024 - science.org
Disruptions in metal balance can trigger a synergistic interplay of cuproptosis and
ferroptosis, offering promising solutions to enduring challenges in oncology. Here, we have …

An intelligent cell-derived nanorobot bridges synergistic crosstalk between sonodynamic therapy and cuproptosis to promote cancer treatment

K Chen, A Zhou, X Zhou, Y Liu, Y Xu, X Ning - Nano Letters, 2023 - ACS Publications
Recent progress in cuproptosis sheds light on the development of treatment approaches for
advancing sonodynamic therapy (SDT) due to its unique cell death mechanism. Herein, we …

Elesclomol loaded copper oxide nanoplatform triggers cuproptosis to enhance antitumor immunotherapy

X Lu, X Chen, C Lin, Y Yi, S Zhao, B Zhu… - Advanced …, 2024 - Wiley Online Library
The induction of cuproptosis, a recently identified form of copper‐dependent immunogenic
cell death, is a promising approach for antitumor therapy. However, sufficient accumulation …

[HTML][HTML] Cuproptosis scoring system to predict the clinical outcome and immune response in bladder cancer

Q Song, R Zhou, F Shu, W Fu - Frontiers in immunology, 2022 - frontiersin.org
Cuproptosis is a novel copper ion-dependent cell death type being regulated in cells, and
this is quite different from the common cell death patterns such as apoptosis, pyroptosis …

Cuproptosis correlates with immunosuppressive tumor microenvironment based on pan-cancer multiomics and single-cell sequencing analysis

Y Qin, Y Liu, X **ang, X Long, Z Chen, X Huang… - Molecular cancer, 2023 - Springer
Recent studies suggest that cuproptosis, a novel mode of cell death, may be associated with
the development of cancer. However, no studies are showing its role in tumorigenesis …

Carrier‐Free Self‐Assembly Nano‐Sonosensitizers for Sonodynamic‐Amplified Cuproptosis‐Ferroptosis in Glioblastoma Therapy

Y Zhu, X Niu, C Ding, Y Lin, W Fang, L Yan… - Advanced …, 2024 - Wiley Online Library
Cuproptosis is a newly discovered form of programmed cell death significantly depending
on the transport efficacy of copper (Cu) ionophores. However, existing Cu ionophores …