The rise of antibiotic resistance and a dwindling antimicrobial pipeline have been
recognized as emerging threats to public health. The ESKAPE pathogens—Enterococcus …

Staphylococcus aureus is capable of becoming resistant to all classes of antibiotics clinically
available and resistance can develop through de novo mutations in chromosomal genes or …

Daptomycin is a cyclic lipopeptide antibiotic used for the treatment of Gram-positive
infections including complicated skin and skin structure infections, right-sided infective …

Abstract Objective Methicillin-resistant Staphylococcus aureus (MRSA) and methicillin-
resistant coagulase-negative Staphylococcus (MRCoNS) are among the main causes of …

Staphylococcus aureus is one of the leading hospital-associated and community-associated
pathogens, which has caused a global public health concern. The emergence of methicillin …

The polymyxin and lipopeptide classes of antibiotics are membrane-targeting drugs of last
resort used to treat infections caused by multi-drug-resistant pathogens. Despite similar …

Lipopeptides are natural product antibiotics that consist of a peptide core with a lipid tail with
a diverse array of target organisms and mechanisms of action. Daptomycin (DAP) is an …

Methicillin-resistant Staphylococcus aureus (MRSA) pose a significant health threat as they
tend to cause severe infections in vulnerable populations and are difficult to treat due to a …

Methicillin-resistant Staphylococcus aureus (MRSA) is one of the most successful human
pathogens with the potential to cause significant morbidity and mortality. MRSA has …

Staphylococcus aureus, a notorious pathogen with versatile virulence, poses a significant
challenge to current antibiotic treatments due to its ability to develop resistance mechanisms …