The complex microenvironment in which malignant tumor cells grow is crucial for cancer
progression. The physical and biochemical characteristics of this niche are involved in …

Innovations in biomaterials and stem cell technology have allowed for the emergence of
novel three-dimensional (3D) tissue-like structures known as organoids and spheroids. As a …

Multicellular spheroids and organoids are promising in vitro 3D models in personalized
medicine and drug screening. They replicate the structural and functional characteristics of …

Enzymes are widely used in industry due to their high efficiency and selectivity. However,
their low stability during certain industrial processes can result in a significant loss of …

Droplet-based microfluidic systems have been employed to manipulate discrete fluid
volumes with immiscible phases. Creating the fluid droplets at microscale has led to a …

Manipulating fluids at varying length scales and understanding their underlying mechanisms
are significant for interdisciplinary studies of physics, chemistry, biology, and engineering; …

Current in-vitro 2D cultures and animal models present severe limitations in recapitulating
human physiopathology with striking discrepancies in estimating drug efficacy and side …

Cancer, one of the most dangerous diseases with a high mortality rate, has attracted much
attention and interest. Advances in tissue engineering and microfluidics have led to the …

The ideal in vitro recreation of the micro-tumor niche—although much needed for a better
understanding of cancer etiology and development of better anticancer therapies—is highly …

Droplet microfluidic techniques have long been known as a high-throughput approach for
cell manipulation. The capacity to compartmentalize cells into picolitre droplets in …