A drug company has to ensure the quality, safety, and efficacy of a marketed drug by
subjecting the drug to a variety of tests [1]. Therefore, drug development is a time-consuming …

Abstract Develo** Quantitative Structure-Activity Relationship (QSAR) models applicable
to general molecules is of great significance for molecular design in many disciplines. This …

Chagas disease chemotherapy, currently based on only two drugs, nifurtimox and
benznidazole, is far from satisfactory and therefore the development of new antichagasic …

In this report, we propose the combination of computational methods and in vivo primary
screening in zebrafish larvae and confirmatory in mice models as a novel strategy to …

Two-dimensional bond-based bilinear indices and linear discriminant analysis are used in
this report to perform a quantitative structure–activity relationship study to identify new …

Electrochemical and ESR studies were carried out in this work with the aim of characterizing
the reduction mechanisms of 4-substituted and 1, 4-disubstituted 7-nitroquinoxalin-2-ones …

Quinoxalinone derivatives, identified as VAM2 compounds (7-nitroquinoxalin-2-ones), were
evaluated against Toxoplasma gondii tachyzoites of the RH strain. The VAM2 compounds …

A selection of 76 nitroheterocycles and related compounds from our in-house compound
library was screened in vitro against the parasite Trypanosoma brucei rhodesiense …

A fluorimetric microassay that uses a redox dye to determine the viability of the flagellate
Trichomonas vaginalis has been optimised to provide a more sensitive method to evaluate …

Abstract Compound 1-methyl-7-nitro-4-(5-(piperidin-1-yl) pentyl)-3, 4-dihydroquinoxalin-2
(1H)-one (VAM2-6) was evaluated against a blood-induced infection with chloroquine …