Seizure prediction—ready for a new era

L Kuhlmann, K Lehnertz, MP Richardson… - Nature Reviews …, 2018 - nature.com
Epilepsy is a common disorder characterized by recurrent seizures. An overwhelming
majority of people with epilepsy regard the unpredictability of seizures as a major issue …

Defining epileptogenic networks: contribution of SEEG and signal analysis

F Bartolomei, S Lagarde, F Wendling, A McGonigal… - …, 2017 - Wiley Online Library
Epileptogenic networks are defined by the brain regions involved in the production and
propagation of epileptic activities. In this review we describe the historical, methodologic …

Neurobehavioural comorbidities of epilepsy: towards a network-based precision taxonomy

BP Hermann, AF Struck, RM Busch, A Reyes… - Nature Reviews …, 2021 - nature.com
Cognitive and behavioural comorbidities are prevalent in childhood and adult epilepsies
and impose a substantial human and economic burden. Over the past century, the classic …

Long-term brain network reorganization predicts responsive neurostimulation outcomes for focal epilepsy

AN Khambhati, A Shafi, VR Rao… - Science Translational …, 2021 - science.org
Responsive neurostimulation (RNS) devices, able to detect imminent seizures and to rapidly
deliver electrical stimulation to the brain, are effective in reducing seizures in some patients …

Coherence a measure of the brain networks: past and present

SM Bowyer - Neuropsychiatric Electrophysiology, 2016 - Springer
Brian connectivity describes the networks of functional and anatomical connections across
the brain. The functional network communications across the brain networks dependent on …

Changing concepts in presurgical assessment for epilepsy surgery

M Zijlmans, W Zweiphenning, N van Klink - Nature Reviews Neurology, 2019 - nature.com
Candidates for epilepsy surgery must undergo presurgical evaluation to establish whether
and how surgical treatment can stop seizures without causing neurological deficits. Various …

The interictal suppression hypothesis in focal epilepsy: network-level supporting evidence

GW Johnson, DJ Doss, VL Morgan, DL Paulo, LY Cai… - Brain, 2023 - academic.oup.com
Why are people with focal epilepsy not continuously having seizures? Previous neuronal
signalling work has implicated gamma-aminobutyric acid balance as integral to seizure …

Predicting neurosurgical outcomes in focal epilepsy patients using computational modelling

N Sinha, J Dauwels, M Kaiser, SS Cash… - Brain, 2017 - academic.oup.com
Abstract See Eissa and Schevon (doi: 10.1093/aww332) for a scientific commentary on this
article. Surgery can be a last resort for patients with intractable, medically refractory epilepsy …

Interictal stereotactic-EEG functional connectivity in refractory focal epilepsies

S Lagarde, N Roehri, I Lambert, A Trebuchon… - Brain, 2018 - academic.oup.com
Drug-refractory focal epilepsies are network diseases associated with functional connectivity
alterations both during ictal and interictal periods. A large majority of studies on the …

Regional and global connectivity disturbances in focal epilepsy, related neurocognitive sequelae, and potential mechanistic underpinnings

DJ Englot, PE Konrad, VL Morgan - Epilepsia, 2016 - Wiley Online Library
Epilepsy is among the most common brain network disorders, and it is associated with
substantial morbidity and increased mortality. Although focal epilepsy was traditionally …