Fluorescent proteins and genetically encoded biosensors

M Wang, Y Da, Y Tian - Chemical Society Reviews, 2023 - pubs.rsc.org
The genetically encoded fluorescent sensors convert chemical and physical signals into
light. They are powerful tools for the visualisation of physiological processes in living cells …

[HTML][HTML] The role of zinc in antiviral immunity

SA Read, S Obeid, C Ahlenstiel, G Ahlenstiel - Advances in nutrition, 2019 - Elsevier
Zinc is an essential trace element that is crucial for growth, development, and the
maintenance of immune function. Its influence reaches all organs and cell types …

[HTML][HTML] A guide to human zinc absorption: general overview and recent advances of in vitro intestinal models

M Maares, H Haase - Nutrients, 2020 - mdpi.com
Zinc absorption in the small intestine is one of the main mechanisms regulating the systemic
homeostasis of this essential trace element. This review summarizes the key aspects of …

Genetically encoded fluorescent biosensors illuminate the spatiotemporal regulation of signaling networks

EC Greenwald, S Mehta, J Zhang - Chemical reviews, 2018 - ACS Publications
Cellular signaling networks are the foundation which determines the fate and function of
cells as they respond to various cues and stimuli. The discovery of fluorescent proteins over …

DNAzyme‐loaded metal–organic frameworks (MOFs) for self‐sufficient gene therapy

H Wang, Y Chen, H Wang, X Liu, X Zhou… - Angewandte …, 2019 - Wiley Online Library
DNAzymes have been recognized as potent therapeutic agents for gene therapy, while their
inefficient intracellular delivery and insufficient cofactor supply precludes their practical …

Discerning the chemistry in individual organelles with small‐molecule fluorescent probes

W Xu, Z Zeng, JH Jiang, YT Chang… - Angewandte Chemie …, 2016 - Wiley Online Library
Principle has it that even the most advanced super‐resolution microscope would be futile in
providing biological insight into subcellular matrices without well‐designed fluorescent …

[HTML][HTML] The biological inorganic chemistry of zinc ions

A Krężel, W Maret - Archives of biochemistry and biophysics, 2016 - Elsevier
The solution and complexation chemistry of zinc ions is the basis for zinc biology. In living
organisms, zinc is redox-inert and has only one valence state: Zn (II). Its coordination …

The role of oxidative stress and hypoxia in pancreatic beta-cell dysfunction in diabetes mellitus

PA Gerber, GA Rutter - Antioxidants & redox signaling, 2017 - liebertpub.com
Significance: Metabolic syndrome is a frequent precursor of type 2 diabetes mellitus (T2D), a
disease that currently affects∼ 8% of the adult population worldwide. Pancreatic beta-cell …

Zinc transporters and their functional integration in mammalian cells

T Kambe, KM Taylor, D Fu - Journal of Biological Chemistry, 2021 - jbc.org
Zinc is a ubiquitous biological metal in all living organisms. The spatiotemporal zinc
dynamics in cells provide crucial cellular signaling opportunities, but also challenges for …

[HTML][HTML] The physiological, biochemical, and molecular roles of zinc transporters in zinc homeostasis and metabolism

T Kambe, T Tsuji, A Hashimoto… - Physiological …, 2015 - journals.physiology.org
Zinc is involved in a variety of biological processes, as a structural, catalytic, and intracellular
and intercellular signaling component. Thus zinc homeostasis is tightly controlled at the …