Benzenes, the most ubiquitous structural moiety in marketed small-molecule drugs, are
frequently associated with poor 'drug-like'properties, including metabolic instability, and poor …

Conspectus Transition-metal catalyzed cross-coupling reactions are fundamental reactions
in organic chemistry, facilitating strategic bond formations for accessing natural products …

The catalytic enantioselective construction of C (sp 3)− C (sp 3) bonds remains a substantial
challenge in organic synthesis. One particularly promising approach is the use of transition …

Electrochemistry has emerged as a powerful means to enable redox transformations in
modern chemical synthesis. This tutorial review delves into the unique advantages of …

Herein we disclose a strategy to promote the hydrocarboxylation of unactivated alkenes
using photochemical activation of formate salts. We illustrate that an alternative initiation …

The selective construction of bridged bicyclic scaffolds has garnered increasing attention
because of their extensive use as saturated bioisosteres of arene in pharmaceutical …

Conspectus After decades of palladium dominating the realm of transition-metal-catalyzed
cross-coupling, recent years have witnessed exciting advances in the development of new …

Much progress has been made in the development of methods to both create compounds
that contain C− F bonds and to functionalize C− F bonds. As such, C− F bonds are becoming …

Carboxylic acids are valuable building blocks for pharmaceutical discovery because of their
chemical stability, commercial availability, and structural diversity. Decarboxylative coupling …

The myriad nickel-catalyzed cross-coupling reactions rely on the formation of an
organonickel intermediate, but limitations in forming monoalkylnickel species have limited …