Targeted drug delivery strategies for precision medicines

MT Manzari, Y Shamay, H Kiguchi, N Rosen… - Nature Reviews …, 2021 - nature.com
Progress in the field of precision medicine has changed the landscape of cancer therapy.
Precision medicine is propelled by technologies that enable molecular profiling, genomic …

Cationic polymers and their therapeutic potential

SK Samal, M Dash, S Van Vlierberghe… - Chemical Society …, 2012 - pubs.rsc.org
The last decade has witnessed enormous research focused on cationic polymers. Cationic
polymers are the subject of intense research as non-viral gene delivery systems, due to their …

Oral delivery of anticancer drugs: challenges and opportunities

K Thanki, RP Gangwal, AT Sangamwar… - Journal of controlled …, 2013 - Elsevier
The present report focuses on the various aspects of oral delivery of anticancer drugs. The
significance of oral delivery in cancer therapeutics has been highlighted which principally …

Nanocarrier mediated delivery of siRNA/miRNA in combination with chemotherapeutic agents for cancer therapy: current progress and advances

NS Gandhi, RK Tekade, MB Chougule - Journal of Controlled Release, 2014 - Elsevier
Chemotherapeutic agents have certain limitations when it comes to treating cancer, the most
important being severe side effects along with multidrug resistance developed against them …

Microencapsulation of protein drugs for drug delivery: strategy, preparation, and applications

G Ma - Journal of Controlled Release, 2014 - Elsevier
Abstract Bio-degradable poly (lactide)(PLA)/poly (lactide–glycolide)(PLGA) and chitosan
microspheres (or microcapsules) have important applications in Drug Delivery Systems …

Chitosan-modified nanocarriers as carriers for anticancer drug delivery: Promises and hurdles

FS Alhodieb, MA Barkat, HA Barkat, H Ab Hadi… - International Journal of …, 2022 - Elsevier
With the advent of drug delivery, various polymeric materials are being explored to fabricate
numerous nanocarriers. Each polymer is associated with a few characteristics attributes …

P-selectin is a nanotherapeutic delivery target in the tumor microenvironment

Y Shamay, M Elkabets, H Li, J Shah, S Brook… - Science translational …, 2016 - science.org
Disseminated tumors are poorly accessible to nanoscale drug delivery systems because of
the vascular barrier, which attenuates extravasation at the tumor site. We investigated P …

Chitosan-based advanced materials for docetaxel and paclitaxel delivery: Recent advances and future directions in cancer theranostics

M Ashrafizadeh, Z Ahmadi, N Mohamadi… - International journal of …, 2020 - Elsevier
Paclitaxel (PTX) and docetaxel (DTX) are key members of taxanes with high anti-tumor
activity against various cancer cells. These chemotherapeutic agents suffer from a number of …

[HTML][HTML] Folic acid (FA)-conjugated mesoporous silica nanoparticles combined with MRP-1 siRNA improves the suppressive effects of myricetin on non-small cell lung …

Y Song, B Zhou, X Du, Y Wang, J Zhang, Y Ai… - Biomedicine & …, 2020 - Elsevier
Non-small cell lung cancer (NSCLC) is a common diagnosed cancer disease worldwide and
its management remains a challenge. Synergistic cancer therapeutic strategy is interesting …

Chitosan nanoparticles prepared by ionotropic gelation: An overview of recent advances

KG Desai - Critical Reviews™ in Therapeutic Drug Carrier …, 2016 - dl.begellhouse.com
The objective of this review is to summarize recent advances in chitosan nanoparticles
prepared by ionotropic gelation. Significant progress has occurred in this area since the …