A RASopathy gene commonly mutated in cancer: the neurofibromatosis type 1 tumour suppressor
N Ratner, SJ Miller - Nature Reviews Cancer, 2015 - nature.com
Abstract Neurofibromatosis type 1 (NF1) is a common genetic disorder that predisposes
affected individuals to tumours. The NF1 gene encodes a RAS GTPase-activating protein …
affected individuals to tumours. The NF1 gene encodes a RAS GTPase-activating protein …
Malignant peripheral nerve sheath tumor: models, biology, and translation
Malignant peripheral nerve sheath tumors (MPNSTs) are aggressive, invasive cancer that
comprise around 10% of all soft tissue sarcomas and develop in about 8–13% of patients …
comprise around 10% of all soft tissue sarcomas and develop in about 8–13% of patients …
PDGFRα+ pericryptal stromal cells are the critical source of Wnts and RSPO3 for murine intestinal stem cells in vivo
Wnts and R-spondins (RSPOs) support intestinal homeostasis by regulating crypt cell
proliferation and differentiation. Ex vivo, Wnts secreted by Paneth cells in organoids can …
proliferation and differentiation. Ex vivo, Wnts secreted by Paneth cells in organoids can …
Malignant peripheral nerve sheath tumors
M Farid, EG Demicco, R Garcia, L Ahn… - The …, 2014 - academic.oup.com
Learning Objectives Explain the characteristics and treatment of malignant peripheral nerve
sheath tumors, both in relation to neurofibromatosis type I and otherwise. Cite the unique …
sheath tumors, both in relation to neurofibromatosis type I and otherwise. Cite the unique …
Molecular mechanisms underpinning sarcomas and implications for current and future therapy
Sarcomas are complex mesenchymal neoplasms with a poor prognosis. Their clinical
management is highly challenging due to their heterogeneity and insensitivity to current …
management is highly challenging due to their heterogeneity and insensitivity to current …
Control of Wnt receptor turnover by R-spondin-ZNRF3/RNF43 signaling module and its dysregulation in cancer
HX Hao, X Jiang, F Cong - Cancers, 2016 - mdpi.com
Aberrant activation of the Wnt/β-catenin pathway is frequently found in various cancers, often
through mutations of downstream components. Inhibiting β-catenin signaling in tumors with …
through mutations of downstream components. Inhibiting β-catenin signaling in tumors with …
Lanatoside C induces G2/M cell cycle arrest and suppresses cancer cell growth by attenuating MAPK, Wnt, JAK-STAT, and PI3K/AKT/mTOR signaling pathways
Cardiac glycosides (CGs) are a diverse family of naturally derived compounds having a
steroid and glycone moiety in their structures. CG molecules inhibit the α-subunit of …
steroid and glycone moiety in their structures. CG molecules inhibit the α-subunit of …
PRC2-inactivating mutations in cancer enhance cytotoxic response to DNMT1-targeted therapy via enhanced viral mimicry
Abstract Polycomb repressive complex 2 (PRC2) has oncogenic and tumor-suppressive
roles in cancer. There is clinical success of targeting this complex in PRC2-dependent …
roles in cancer. There is clinical success of targeting this complex in PRC2-dependent …
Therapeutic targeting of tumor-derived R-spondin attenuates β-catenin signaling and tumorigenesis in multiple cancer types
C Chartier, J Raval, F Axelrod, C Bond, J Cain… - Cancer research, 2016 - AACR
Deregulation of the β-catenin signaling has long been associated with cancer. Intracellular
components of this pathway, including axin, APC, and β-catenin, are frequently mutated in a …
components of this pathway, including axin, APC, and β-catenin, are frequently mutated in a …
Neurofibromatosis type 1: fundamental insights into cell signalling and cancer
E Rad, AR Tee - Seminars in cell & developmental biology, 2016 - Elsevier
Abstract Neurofibromatosis type 1 (NF1) is an autosomal dominant tumour predisposition
syndrome that is caused through loss of function mutations of a tumour suppressor gene …
syndrome that is caused through loss of function mutations of a tumour suppressor gene …