Malignant peripheral nerve sheath tumors (MPNSTs) are aggressive, invasive cancer that
comprise around 10% of all soft tissue sarcomas and develop in about 8–13% of patients …

Abstract Neurofibromatosis type 1 (NF1) is a common genetic disorder that predisposes
affected individuals to tumours. The NF1 gene encodes a RAS GTPase-activating protein …

Wnts and R-spondins (RSPOs) support intestinal homeostasis by regulating crypt cell
proliferation and differentiation. Ex vivo, Wnts secreted by Paneth cells in organoids can …

Learning Objectives Explain the characteristics and treatment of malignant peripheral nerve
sheath tumors, both in relation to neurofibromatosis type I and otherwise. Cite the unique …

Sarcomas are complex mesenchymal neoplasms with a poor prognosis. Their clinical
management is highly challenging due to their heterogeneity and insensitivity to current …

Aberrant activation of the Wnt/β-catenin pathway is frequently found in various cancers, often
through mutations of downstream components. Inhibiting β-catenin signaling in tumors with …

Malignant peripheral nerve sheath tumor (MPNST) is a highly aggressive sarcoma, and a
lethal neurofibromatosis type 1-related malignancy, with little progress made on treatment …

Cardiac glycosides (CGs) are a diverse family of naturally derived compounds having a
steroid and glycone moiety in their structures. CG molecules inhibit the α-subunit of …

Alzheimer's disease (AD) has been a major health issue for more than one century since it
was first reported in 1906. As one of the most common neurodegenerative diseases, AD is …

Deregulation of the β-catenin signaling has long been associated with cancer. Intracellular
components of this pathway, including axin, APC, and β-catenin, are frequently mutated in a …