The statins have been used for 30 years to prevent coronary artery disease and stroke. Their
primary mechanism of action is the lowering of serum cholesterol through inhibiting hepatic …

With cardiovascular disease being the leading cause of morbidity and mortality worldwide,
effective and cost-efficient therapies to reduce cardiovascular risk are highly needed. Lipids …

Rho-associated kinases ROCK1 and ROCK2 are serine/threonine kinases that are
downstream targets of the small GTPases RhoA, RhoB, and RhoC. ROCKs are involved in …

The field of cardiac tissue engineering has made significant strides over the last few
decades, highlighted by the development of human cell derived constructs that have shown …

Malignant tumor cells display uncontrolled proliferation, loss of epithelial cell polarity, altered
interactions with neighboring cells and the surrounding extracellular matrix, and enhanced …

Akt activation supports survival of cardiomyocytes against ischemia/reperfusion, which
induces cell death through opening of the mitochondrial permeability transition pore (PT …

Although several recent publications have suggested that microRNAs contribute to the
pathogenesis of diabetic nephropathy, the role of miRNAs in vivo still remains poorly …

Cardiovascular diseases, the number 1 cause of death worldwide, are frequently associated
with apoptotic death of cardiac myocytes. Since cardiomyocyte apoptosis is a highly …

The saturated medium-chain fatty-acid lauric acid (LA) has been associated to certain health-
promoting benefits of coconut oil intake, including the improvement of the quality of life in …

G protein‐coupled receptors (GPCRs) represent a large family of seven transmembrane
receptors, which communicate extracellular signals into the cellular lumen. The human …