Treatment of bipolar disorder
We review recent developments in the acute and long-term treatment of bipolar disorder and
identify promising future routes to therapeutic innovation. Overall, advances in drug …
identify promising future routes to therapeutic innovation. Overall, advances in drug …
Calcium signalling and psychiatric disease: bipolar disorder and schizophrenia
MJ Berridge - Cell and tissue research, 2014 - Springer
Neurons have highly developed Ca 2+ signalling systems responsible for regulating many
neural functions such as the generation of brain rhythms, information processing and the …
neural functions such as the generation of brain rhythms, information processing and the …
Molecular mechanisms of bipolar disorder: progress made and future challenges
Bipolar disorder (BD) is a chronic and progressive psychiatric illness characterized by mood
oscillations, with episodes of mania and depression. The impact of BD on patients can be …
oscillations, with episodes of mania and depression. The impact of BD on patients can be …
Lithium: bipolar disorder and neurodegenerative diseases Possible cellular mechanisms of the therapeutic effects of lithium
F Marmol - Progress in Neuro-Psychopharmacology and …, 2008 - Elsevier
Bipolar illness is a major psychiatric disorder that affects 1–3% of the worldwide population.
Epidemiological studies have demonstrated that this illness is substantially heritable …
Epidemiological studies have demonstrated that this illness is substantially heritable …
Animal models for bipolar disorder: from bedside to the cage
Bipolar disorder is characterized by recurrent manic and depressive episodes. Patients
suffering from this disorder experience dramatic mood swings with a wide variety of typical …
suffering from this disorder experience dramatic mood swings with a wide variety of typical …
Lithium: the pharmacodynamic actions of the amazing ion
KM Brown, DK Tracy - Therapeutic advances in …, 2013 - journals.sagepub.com
Lithium has been used for the treatment of mood disorders for over 60 years, yet the exact
mechanisms by which it exerts its therapeutic effects remain unclear. Two enzymatic chains …
mechanisms by which it exerts its therapeutic effects remain unclear. Two enzymatic chains …
Characterization of the Expression and Regulation of Genes Necessary for myo-Inositol Biosynthesis and Transport in the Seminiferous Epithelium
In many mammals, the concentration of myo-inositol in the fluid of the seminiferous tubules
is dramatically higher than levels found in serum. Two enzymes involved in myo-inositol …
is dramatically higher than levels found in serum. Two enzymes involved in myo-inositol …
Mammalian inositol 3-phosphate synthase: its role in the biosynthesis of brain inositol and its clinical use as a psychoactive agent
LK Parthasarathy, L Ratnam, S Seelan… - Biology of Inositols and …, 2006 - Springer
1. INTRODUCTION myo-inositol, 1 a carbocyclic sugar that is abundant in brain and other
mammalian tissues, mediates cell signal transduction in response to a variety of hormones …
mammalian tissues, mediates cell signal transduction in response to a variety of hormones …
The subtherapeutic dose of valproic acid induces the activity of cardiolipin-dependent proteins
P Horonyova, I Durisova, P Cermakova… - … et Biophysica Acta (BBA …, 2024 - Elsevier
A mood-stabilizing anticonvulsant valproic acid (VPA) is a drug with a pleiotropic effect on
cells. Here, we describe the impact of VPA on the metabolic function of human HAP1 cells …
cells. Here, we describe the impact of VPA on the metabolic function of human HAP1 cells …
Human 1-D-myo-inositol-3-phosphate synthase is functional in yeast
We have cloned, sequenced, and expressed a human cDNA encoding 1-d-myo-inositol-3-
phosphate (MIP) synthase (hINO1). The encoded 62-kDa human enzyme converted d …
phosphate (MIP) synthase (hINO1). The encoded 62-kDa human enzyme converted d …