Disulfide bond formation is probably involved in the biogenesis of approximately one third of
human proteins. A central player in this essential process is protein disulfide isomerase or …

Living cells must be able to respond to physiological and environmental fluctuations that
threaten cell function and viability. A cellular event prone to disruption by a wide variety of …

The endoplasmic reticulum (ER) is a multifunctional organelle that constitutes the entry into
the secretory pathway. The ER contributes to the maintenance of cellular calcium …

Aims: The endoplasmic reticulum (ER) is involved in many functions, including protein
folding, redox homeostasis, and Ca2+ storage and signaling. To perform these multiple …

Disulfide bonds play a pivotal role in maintaining the natural structures of proteins to ensure
their performance of normal biological functions. Moreover, biological molecular assembly …

Introduction of disulfide bonds into proteins entering the secretory pathway is catalyzed by
Ero1p, which generates disulfide bonds de novo, and Pdi1p, which transfers disulfides to …

Oxidative maturation of secretory and membrane proteins in the endoplasmic reticulum (ER)
is powered by Ero1 oxidases. To prevent cellular hyperoxidation, Ero1 activity can be …

Aims: Ero1 flavoproteins catalyze oxidative folding in the endoplasmic reticulum (ER),
consuming oxygen and generating hydrogen peroxide (H2O2). The ER-localized …

Reversible protein S-nitrosylation regulates a wide range of biological functions and
physiological activities in plants. However, it is challenging to quantitively determine the S …

In the endoplasmic reticulum (ER) of eukaryotic cells, Ero1 flavoenzymes promote oxidative
protein folding through protein disulphide isomerase (PDI), generating reactive oxygen …