Epithelial-mesenchymal transition and metabolic switching in cancer: lessons from somatic cell reprogramming
Epithelial-mesenchymal transition (EMT) and its critical roles during cancer progression
have long been recognized and extensively reviewed. Recent studies on the generation of …
have long been recognized and extensively reviewed. Recent studies on the generation of …
Histone deacetylase complexes: Structure, regulation and function
MD Asmamaw, A He, LR Zhang, HM Liu… - Biochimica et Biophysica …, 2024 - Elsevier
Histone deacetylases (HDACs) are key epigenetic regulators, and transcriptional complexes
with deacetylase function are among the epigenetic corepressor complexes in the nucleus …
with deacetylase function are among the epigenetic corepressor complexes in the nucleus …
[HTML][HTML] Circulating tumor cell clustering shapes DNA methylation to enable metastasis seeding
S Gkountela, F Castro-Giner, BM Szczerba, M Vetter… - Cell, 2019 - cell.com
The ability of circulating tumor cells (CTCs) to form clusters has been linked to increased
metastatic potential. Yet biological features and vulnerabilities of CTC clusters remain …
metastatic potential. Yet biological features and vulnerabilities of CTC clusters remain …
Chromatin accessibility dynamics during iPSC reprogramming
Cell-fate decisions remain poorly understood at the chromatin level. Here, we map
chromatin remodeling dynamics during induction of pluripotent stem cells. ATAC-seq …
chromatin remodeling dynamics during induction of pluripotent stem cells. ATAC-seq …
[HTML][HTML] Transposable elements are regulated by context-specific patterns of chromatin marks in mouse embryonic stem cells
The majority of mammalian genomes are devoted to transposable elements (TEs). Whilst
TEs are increasingly recognized for their important biological functions, they are a potential …
TEs are increasingly recognized for their important biological functions, they are a potential …
Co-repressor, co-activator and general transcription factor: the many faces of the Sin3 histone deacetylase (HDAC) complex
GE Adams, A Chandru, SM Cowley - Biochemical Journal, 2018 - portlandpress.com
At face value, the Sin3 histone deacetylase (HDAC) complex appears to be a prototypical co-
repressor complex, that is, a multi-protein complex recruited to chromatin by DNA bound …
repressor complex, that is, a multi-protein complex recruited to chromatin by DNA bound …
MYC competes with MiT/TFE in regulating lysosomal biogenesis and autophagy through an epigenetic rheostat
I Annunziata, D van de Vlekkert, E Wolf… - Nature …, 2019 - nature.com
Coordinated regulation of the lysosomal and autophagic systems ensures basal catabolism
and normal cell physiology, and failure of either system causes disease. Here we describe …
and normal cell physiology, and failure of either system causes disease. Here we describe …
Two assembly modes for SIN3 histone deacetylase complexes
Abstract The switch-independent 3 (SIN3)/histone deacetylase (HDAC) complexes play
essential roles in regulating chromatin accessibility and gene expression. There are two …
essential roles in regulating chromatin accessibility and gene expression. There are two …
[HTML][HTML] HDAC2 as a target for develo** anti-cancer drugs
Histone deacetylases (HDACs) deacetylate histones H3 and H4. An imbalance between
histone acetylation and deacetylation can lead to various diseases. HDAC2 is present in the …
histone acetylation and deacetylation can lead to various diseases. HDAC2 is present in the …
ZBTB12 is a molecular barrier to dedifferentiation in human pluripotent stem cells
Abstract Development is generally viewed as one-way traffic of cell state transition from
primitive to developmentally advanced states. However, molecular mechanisms that ensure …
primitive to developmentally advanced states. However, molecular mechanisms that ensure …