malERA: an updated research agenda for malaria elimination and eradication
Achieving a malaria-free world presents exciting scientific challenges as well as
overwhelming health, equity, and economic benefits. WHO and countries are setting …
overwhelming health, equity, and economic benefits. WHO and countries are setting …
The development of malaria parasites in the mosquito midgut
The mosquito midgut stages of malaria parasites are crucial for establishing an infection in
the insect vector and to thus ensure further spread of the pathogen. Parasite development in …
the insect vector and to thus ensure further spread of the pathogen. Parasite development in …
[HTML][HTML] Functional profiling of a Plasmodium genome reveals an abundance of essential genes
The genomes of malaria parasites contain many genes of unknown function. To assist drug
development through the identification of essential genes and pathways, we have measured …
development through the identification of essential genes and pathways, we have measured …
Plasmodium ARK2 and EB1 drive unconventional spindle dynamics, during chromosome segregation in sexual transmission stages
The Aurora family of kinases orchestrates chromosome segregation and cytokinesis during
cell division, with precise spatiotemporal regulation of its catalytic activities by distinct protein …
cell division, with precise spatiotemporal regulation of its catalytic activities by distinct protein …
A PPP-type pseudophosphatase is required for the maintenance of basal complex integrity in Plasmodium falciparum
AA Morano, RM Rudlaff, JD Dvorin - Nature Communications, 2023 - nature.com
During its asexual blood stage, P. falciparum replicates via schizogony, wherein dozens of
daughter cells are formed within a single parent. The basal complex, a contractile ring that …
daughter cells are formed within a single parent. The basal complex, a contractile ring that …
Division and transmission: malaria parasite development in the mosquito
The malaria parasite life cycle alternates between two hosts: a vertebrate and the female
Anopheles mosquito vector. Cell division, proliferation, and invasion are essential for …
Anopheles mosquito vector. Cell division, proliferation, and invasion are essential for …
Artemisinin resistance without pfkelch13 mutations in Plasmodium falciparum isolates from Cambodia
Background Artemisinin resistance is associated with delayed parasite clearance half-life in
vivo and correlates with ring-stage survival under dihydroartemisinin in vitro. Both …
vivo and correlates with ring-stage survival under dihydroartemisinin in vitro. Both …
[HTML][HTML] Genome-scale identification of essential metabolic processes for targeting the Plasmodium liver stage
Plasmodium gene functions in mosquito and liver stages remain poorly characterized due to
limitations in the throughput of phenoty** at these stages. To fill this gap, we followed …
limitations in the throughput of phenoty** at these stages. To fill this gap, we followed …
Glucose-mediated proliferation of a gut commensal bacterium promotes Plasmodium infection by increasing mosquito midgut pH
M Wang, Y An, L Gao, S Dong, X Zhou, Y Feng… - Cell reports, 2021 - cell.com
Plant-nectar-derived sugar is the major energy source for mosquitoes, but its influence on
vector competence for malaria parasites remains unclear. Here, we show that Plasmodium …
vector competence for malaria parasites remains unclear. Here, we show that Plasmodium …
Conditional degradation of Plasmodium calcineurin reveals functions in parasite colonization of both host and vector
Functional analysis of essential genes in the malarial parasite, Plasmodium, is hindered by
lack of efficient strategies for conditional protein regulation. We report the development of a …
lack of efficient strategies for conditional protein regulation. We report the development of a …