Alzheimer's disease (AD) is the most prevalent form of dementia, with complex
pathophysiology that is not fully understood. While β‐amyloid plaque and neurofibrillary …

As the median age of the population increases, the number of individuals with Alzheimer's
disease (AD) and the associated socio-economic burden are predicted to worsen. While …

Medical imaging has enormous potential for early disease prediction, but is impeded by the
difficulty and expense of acquiring data sets before symptom onset. UK Biobank aims to …

Perturbations in iron homeostasis and iron accumulation feature in several
neurodegenerative disorders including Alzheimer's disease (AD), Parkinson's disease (PD) …

Susceptibility to the biological consequences of aging varies among organs and individuals.
We analyzed hepatocyte transcriptomes of healthy young and aged male mice to generate …

Objective: To explore whether serum neurofilament light chain protein (NfL) levels are
increased in patients with MRI-confirmed recent small subcortical infarcts (RSSI) compared …

Despite loss of grey matter volume and emergence of distinct cognitive deficits in young
adults diagnosed with schizophrenia, current treatments for schizophrenia do not target …

Iron oxide nanoparticles (IONPs) have been proposed as targeted carriers to deliver
therapeutic molecules in the central nervous system (CNS). However, IONPs may damage …

Metals are the oldest toxins known to humans. Metals differ from other toxic substances in
that they are neither created nor destroyed by humans (Casarett and Doull's, Toxicology: the …

Motor neuron diseases (MNDs) like amyotrophic lateral sclerosis (ALS) are progressive
neurodegenerative disorders affecting upper and lower motor neurons (UMN and LMN) …