Glaucoma: the retina and beyond

BM Davis, L Crawley, M Pahlitzsch, F Javaid… - Acta …, 2016 - Springer
Over 60 million people worldwide are diagnosed with glaucomatous optic neuropathy,
which is estimated to be responsible for 8.4 million cases of irreversible blindness globally …

MR imaging of papilledema and visual pathways: effects of increased intracranial pressure and pathophysiologic mechanisms

N Passi, AJ Degnan, LM Levy - American Journal of Neuroradiology, 2013 - ajnr.org
Papilledema, defined as swelling of the optic disc, frequently occurs in the setting of
increased ICP and in a variety of medical conditions, including pseudotumor cerebri, sinus …

Advanced functional nanomaterials for theranostics

H Huang, JF Lovell - Advanced functional materials, 2017 - Wiley Online Library
Nanoscale materials have been explored extensively as agents for therapeutic and
diagnostic (ie, theranostic) applications. Research efforts have shifted from exploring new …

The cell and molecular biology of glaucoma: axonopathy and the brain

DJ Calkins, PJ Horner - Investigative ophthalmology & visual …, 2012 - iovs.arvojournals.org
Many ophthalmologists and members of the lay public alike view glaucoma in its historical
context—that is, as exclusively a disease of the eye. This view has been (and remains) …

NAP (davunetide) modifies disease progression in a mouse model of severe neurodegeneration: protection against impairments in axonal transport

Y Jouroukhin, R Ostritsky, Y Assaf, G Pelled… - Neurobiology of …, 2013 - Elsevier
NAP (davunetide) is a novel neuroprotective compound with mechanism of action that
appears to involve microtubule (MT) stabilization and repair. To evaluate, for the first time …

[HTML][HTML] Citicoline modulates glaucomatous neurodegeneration through intraocular pressure-independent control

Y van der Merwe, MC Murphy, JR Sims, MA Faiq… - …, 2021 - Elsevier
Glaucoma is a neurodegenerative disease that causes progressive, irreversible vision loss.
Currently, intraocular pressure (IOP) is the only modifiable risk factor for glaucoma …

Manganese-enhanced magnetic resonance imaging: overview and central nervous system applications with a focus on neurodegeneration

RA Cloyd, SA Koren, JF Abisambra - Frontiers in aging neuroscience, 2018 - frontiersin.org
Manganese-enhanced magnetic resonance imaging (MEMRI) rose to prominence in the
1990s as a sensitive approach to high contrast imaging. Following the discovery of …

Effect of Lycium Barbarum (Wolfberry) Polysaccharides on Preserving Retinal Function after Partial Optic Nerve Transection

PHW Chu, HY Li, MP Chin, K So, HHL Chan - PLoS One, 2013 - journals.plos.org
Lycium Barbarum Polysaccharides (LBP) are the active components of Wolfberry (a
traditional Chinese medicine) which has long been used for improving visual function. This …

Age-related changes in eye, brain and visuomotor behavior in the DBA/2J mouse model of chronic glaucoma

XL Yang, Y Van Der Merwe, J Sims, C Parra, LC Ho… - Scientific reports, 2018 - nature.com
Although elevated intraocular pressure (IOP) and age are major risk factors for glaucoma,
their effects on glaucoma pathogenesis remain unclear. This study examined the onset and …

Mechanisms implicated in the contralateral effect in the central nervous system after unilateral injury: Focus on the visual system

F Lucas-Ruiz, C Galindo-Romero… - Neural Regeneration …, 2021 - journals.lww.com
The retina, as part of the central nervous system is an ideal model to study the response of
neurons to injury and disease and to test new treatments. During the last decade is …