The heart is the most metabolically active organ in the human body, and cardiac metabolism
has been studied for decades. However, the bulk of studies have focused on animal models …

Skeletal muscle phosphorus‐31 31P MRS is the oldest MRS methodology to be applied to
in vivo metabolic research. The technical requirements of 31P MRS in skeletal muscle …

This paper offers a critical review of the properties, methods and potential clinical application
of sodium (23Na) MRI in human heart. Because the tissue sodium concentration (TSC) in …

Background: Abnormalities in cardiac energy metabolism occur in heart failure (HF) and
contribute to contractile dysfunction, but their role, if any, in HF-related pathologic …

BACKGROUND Physical frailty in older individuals is characterized by subjective symptoms
of fatigue and exercise intolerance (EI). Objective abnormalities in skeletal muscle (SM) …

Abstract Purpose To confirm that CrCEST in muscle exhibits a slow‐exchanging process,
and to obtain high‐resolution amide, creatine (Cr), and phosphocreatine (PCr) maps of …

Background It has been hypothesized that the supply of chemical energy may be insufficient
to fuel normal mechanical pump function in heart failure (HF). The creatine kinase (CK) …

The purpose of this work was to develop a 31P spectroscopic magnetic resonance
fingerprinting (MRF) method for fast quantification of the chemical exchange rate between …

Background: Many heart diseases can result in reduced pum** capacity of the heart
muscle. A mismatch between ATP demand and ATP production of cardiomyocytes is one of …

Purpose To investigate the feasibility of rapid CEST MRI acquisition for evaluating oxidative
phosphorylation (OXPHOS) in human skeletal muscle at 3T, utilizing ultrafast Z …