Potential of mesenchymal stem cells in gene therapy approaches for inherited and acquired diseases

J Reiser, XY Zhang, CS Hemenway… - Expert opinion on …, 2005 - Taylor & Francis
The intriguing biology of stem cells and their vast clinical potential is emerging rapidly for
gene therapy. Bone marrow stem cells, including the pluripotent haematopoietic stem cells …

Gene therapy: design and prospects for craniofacial regeneration

EL Scheller, PH Krebsbach - Journal of dental research, 2009 - journals.sagepub.com
Gene therapy is defined as the treatment of disease by transfer of genetic material into cells.
This review will explore methods available for gene transfer as well as current and potential …

[HTML][HTML] The coronary delivery of marrow stromal cells for myocardial regeneration: pathophysiologic and therapeutic implications

JS Wang, D Shum-Tim, E Chedrawy… - The Journal of thoracic and …, 2001 - Elsevier
Objectives: Bone marrow stromal cells contain “adult stem cells.” We tested the hypothesis
that coronary-infused bone marrow stromal cells may populate the infarcted heart and …

Postnatal bone marrow stromal cells elicit a potent VEGF-dependent neoangiogenic response in vivo

A Al-Khaldi, N Eliopoulos, D Martineau, L Lejeune… - Gene therapy, 2003 - nature.com
Bone marrow stromal cells (MSCs) are pluripotent cells capable of differentiation into
several tissue types. This present study was performed to determine their functional …

Development of a scalable process for high‐yield lentiviral vector production by transient transfection of HEK293 suspension cultures

S Ansorge, S Lanthier, J Transfiguracion… - The Journal of Gene …, 2009 - Wiley Online Library
Background Lentiviral vectors (LV) offer several advantages over other gene delivery
vectors. Their potential for the integration and long‐term expression of therapeutic genes …

Lentiviral vectors for sustained transgene expression in human bone marrow–derived stromal cells

XY Zhang, VF La Russa, L Bao, J Kolls… - Molecular Therapy, 2002 - cell.com
Bone marrow–derived mesenchymal stromal cells (MSCs) have attracted attention as
potential platforms for the systemic delivery of therapeutic proteins in vivo following gene …

Transduction of bone-marrow-derived mesenchymal stem cells by using lentivirus vectors pseudotyped with modified RD114 envelope glycoproteins

XY Zhang, VF La Russa, J Reiser - Journal of virology, 2004 - Am Soc Microbiol
Bone-marrow-derived mesenchymal stem cells (MSCs) have attracted considerable
attention as tools for the systemic delivery of therapeutic proteins in vivo, and the ability to …

Mobilization and homing of bone marrow stromal cells in myocardial infarction

B Bittira, D Shum-Tim, A Al-Khaldi… - European Journal of …, 2003 - academic.oup.com
Abstract Objective: Marrow stromal cells (MSCs) contain multipotent cells, which may
participate in the repair of damaged organs. We tested the hypothesis that MSCs are …

[HTML][HTML] Transcoronary implantation of bone marrow stromal cells ameliorates cardiac function after myocardial infarction

T Saito, JQ Kuang, CCH Lin, RCJ Chiu - The Journal of Thoracic and …, 2003 - Elsevier
OBJECTIVES: Bone marrow stromal cells are capable of differentiating into cardiomyogenic
cells. We tested the hypothesis that transcoronary implantation of bone marrow stromal cells …

Size-exclusion chromatography purification of high-titer vesicular stomatitis virus G glycoprotein-pseudotyped retrovectors for cell and gene therapy applications

J Transfiguracion, DE Jaalouk, K Ghani… - Human gene …, 2003 - liebertpub.com
Vesicular stomatitis virus G glycoprotein (VSV-G)-pseudotyped replication-defective
retroviral particles are pantropic and amenable to concentration to high titer by …