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Circular Engineered Sortase for Interrogating Histone H3 in Chromatin
Reversible modification of the histone H3 N-terminal tail is critical in regulating the chromatin
structure, gene expression, and cell states, while its dysregulation contributes to disease …
structure, gene expression, and cell states, while its dysregulation contributes to disease …
Efficient Chemical Synthesis of Multi-Monoubiquitylated and Diubiquitylated Histones by the α-Halogen Ketone-Mediated Strategy
S Peng, X Liu, C Lu, H Wang, X Liu, Q Gong… - Bioconjugate …, 2024 - ACS Publications
The chemical synthesis of homogeneously ubiquitylated histones is a powerful approach to
decipher histone ubiquitylation-dependent epigenetic regulation. Among the various …
decipher histone ubiquitylation-dependent epigenetic regulation. Among the various …
RAD18-catalysed formation of ubiquitination intermediate mimic of proliferating cell nuclear antigen PCNA
Abstract The 2-((2-chloroethyl) amino) ethane-1-thiol (CAET)-based chemical trap**
strategy is a practical tool for mechanistic studies of E3-catalysed ubiquitination. However …
strategy is a practical tool for mechanistic studies of E3-catalysed ubiquitination. However …
Sequential release of interacting proteins and Ub-modifying enzymes by disulfide heterotypic ubiquitin reagents
Heterotypic ubiquitin (Ub) chains have emerged as fundamental components in a wide
range of cellular processes. The integrative identification of Ub-interacting proteins (readers) …
range of cellular processes. The integrative identification of Ub-interacting proteins (readers) …