Training the circadian clock, clocking the drugs, and drugging the clock to prevent, manage, and treat chronic diseases
Daily rhythms in behavior, physiology, and metabolism are an integral part of homeostasis.
These rhythms emerge from interactions between endogenous circadian clocks and …
These rhythms emerge from interactions between endogenous circadian clocks and …
Time-restricted eating: benefits, mechanisms, and challenges in translation
Eating out of phase with daily circadian rhythms induces metabolic desynchrony in
peripheral metabolic organs and may increase chronic disease risk. Time-restricted eating …
peripheral metabolic organs and may increase chronic disease risk. Time-restricted eating …
Circadian influences of diet on the microbiome and immunity
Host circadian rhythmicity and the timing of feeding are increasingly recognized to cross-
regulate and entrain each other, and may play crucial roles in regulating multiple …
regulate and entrain each other, and may play crucial roles in regulating multiple …
Immunometabolism around the Clock
RG Carroll, GA Timmons, MP Cervantes-Silva… - Trends in molecular …, 2019 - cell.com
Almost every cell has a molecular clock, which controls gene expression on a 24-h cycle,
providing circadian rhythmicity. An example of a circadian behaviour common to most …
providing circadian rhythmicity. An example of a circadian behaviour common to most …
[HTML][HTML] Time-restricted feeding affects the fecal microbiome metabolome and its diurnal oscillations in lung cancer mice
G Fang, S Wang, Q Chen, H Luo, X Lian, D Shi - Neoplasia, 2023 - Elsevier
The homeostasis of the gut microbiota and circadian rhythm is critical to host health, and
both are inextricably intertwined with lung cancer. Although time-restricted feeding (TRF) …
both are inextricably intertwined with lung cancer. Although time-restricted feeding (TRF) …
Macrophage meets the circadian clock: implication of the circadian clock in the role of macrophages in acute lower respiratory tract infection
K Shirato, S Sato - Frontiers in Cellular and Infection Microbiology, 2022 - frontiersin.org
The circadian rhythm is a biological system that creates daily variations of physiology and
behavior with a 24-h cycle, which is precisely controlled by the molecular circadian clock …
behavior with a 24-h cycle, which is precisely controlled by the molecular circadian clock …
Time restricted feeding modifies leukocyte responsiveness and improves inflammation outcome
K Ella, ÁR Sűdy, Z Búr, B Koós, ÁS Kisiczki… - Frontiers in …, 2022 - frontiersin.org
Time restricted eating, the dietary approach limiting food intake to a maximal 10-hour period
of daytime is considered beneficial in metabolic dysfunctions, such as obesity and diabetes …
of daytime is considered beneficial in metabolic dysfunctions, such as obesity and diabetes …
Time restricted feeding decreases renal innate immune cells and blood pressure in hypertensive mice
BM Sims, BL Goodlett, ML Allbee, EJ Pickup… - Journal of …, 2022 - journals.lww.com
Background: Renal innate immune cell accumulation and inflammation are associated with
hypertension. Time restricted feeding (TRF) has been reported to decrease inflammation …
hypertension. Time restricted feeding (TRF) has been reported to decrease inflammation …
Intertwining roles of circadian and metabolic regulation of the innate immune response
SL Cox, JR O'Siorain, LE Fagan, AM Curtis… - Seminars in …, 2022 - Springer
It has emerged that an interconnected relationship exists between metabolism, circadian
rhythms, and the immune system. The relationship between metabolism and circadian …
rhythms, and the immune system. The relationship between metabolism and circadian …
Effects and possible mechanisms of intermittent fasting on health and disease: A narrative review
Z Li, L Huang, Y Luo, B Yu, G Tian - Nutrition Reviews, 2023 - academic.oup.com
The imbalance between energy intake and expenditure in an environment of continuous
food availability can lead to metabolic disturbances in the body and increase the risk of …
food availability can lead to metabolic disturbances in the body and increase the risk of …