Training the circadian clock, clocking the drugs, and drugging the clock to prevent, manage, and treat chronic diseases

G Sulli, ENC Manoogian, PR Taub, S Panda - Trends in pharmacological …, 2018 - cell.com
Daily rhythms in behavior, physiology, and metabolism are an integral part of homeostasis.
These rhythms emerge from interactions between endogenous circadian clocks and …

Time-restricted eating: benefits, mechanisms, and challenges in translation

P Regmi, LK Heilbronn - Iscience, 2020 - cell.com
Eating out of phase with daily circadian rhythms induces metabolic desynchrony in
peripheral metabolic organs and may increase chronic disease risk. Time-restricted eating …

Circadian influences of diet on the microbiome and immunity

D Zheng, K Ratiner, E Elinav - Trends in immunology, 2020 - cell.com
Host circadian rhythmicity and the timing of feeding are increasingly recognized to cross-
regulate and entrain each other, and may play crucial roles in regulating multiple …

Immunometabolism around the Clock

RG Carroll, GA Timmons, MP Cervantes-Silva… - Trends in molecular …, 2019 - cell.com
Almost every cell has a molecular clock, which controls gene expression on a 24-h cycle,
providing circadian rhythmicity. An example of a circadian behaviour common to most …

[HTML][HTML] Time-restricted feeding affects the fecal microbiome metabolome and its diurnal oscillations in lung cancer mice

G Fang, S Wang, Q Chen, H Luo, X Lian, D Shi - Neoplasia, 2023 - Elsevier
The homeostasis of the gut microbiota and circadian rhythm is critical to host health, and
both are inextricably intertwined with lung cancer. Although time-restricted feeding (TRF) …

Macrophage meets the circadian clock: implication of the circadian clock in the role of macrophages in acute lower respiratory tract infection

K Shirato, S Sato - Frontiers in Cellular and Infection Microbiology, 2022 - frontiersin.org
The circadian rhythm is a biological system that creates daily variations of physiology and
behavior with a 24-h cycle, which is precisely controlled by the molecular circadian clock …

Time restricted feeding modifies leukocyte responsiveness and improves inflammation outcome

K Ella, ÁR Sűdy, Z Búr, B Koós, ÁS Kisiczki… - Frontiers in …, 2022 - frontiersin.org
Time restricted eating, the dietary approach limiting food intake to a maximal 10-hour period
of daytime is considered beneficial in metabolic dysfunctions, such as obesity and diabetes …

Time restricted feeding decreases renal innate immune cells and blood pressure in hypertensive mice

BM Sims, BL Goodlett, ML Allbee, EJ Pickup… - Journal of …, 2022 - journals.lww.com
Background: Renal innate immune cell accumulation and inflammation are associated with
hypertension. Time restricted feeding (TRF) has been reported to decrease inflammation …

Intertwining roles of circadian and metabolic regulation of the innate immune response

SL Cox, JR O'Siorain, LE Fagan, AM Curtis… - Seminars in …, 2022 - Springer
It has emerged that an interconnected relationship exists between metabolism, circadian
rhythms, and the immune system. The relationship between metabolism and circadian …

Effects and possible mechanisms of intermittent fasting on health and disease: A narrative review

Z Li, L Huang, Y Luo, B Yu, G Tian - Nutrition Reviews, 2023 - academic.oup.com
The imbalance between energy intake and expenditure in an environment of continuous
food availability can lead to metabolic disturbances in the body and increase the risk of …