All life forms have an absolute requirement for metals, as metals play critical roles in
fundamental processes, including osmotic regulation, catalysis, metabolism …

Copper is an essential micronutrient involved in fundamental life processes that are
conserved throughout all forms of life. The ability of copper to catalyze oxidation–reduction …

Copper is an essential cofactor for all organisms, and yet it becomes toxic if concentrations
exceed a threshold maintained by evolutionarily conserved homeostatic mechanisms. How …

Skin cutaneous melanoma (SKCM, hereafter referred to as melanoma) is the most lethal
skin cancer with increasing incidence. Regulated cell death plays an important role in …

Copper serves as a co-factor for a host of metalloenzymes that contribute to malignant
progression. The orally bioavailable copper chelating agent tetrathiomolybdate (TM) has …

Increased intracellular toxicity due to an imbalance in copper homeostasis caused by
copper ion accumulation could regulate the rate of cancer cell growth and proliferation. The …

Metallomodulation cell death strategies are extensively investigated for antitumor therapy,
such as cuproptosis, ferroptosis, and chemodynamic therapy (CDT). Undoubtedly, the …

Life on Earth has evolved within a complex mixture of organic and inorganic compounds.
While organic molecules such as amino acids, carbohydrates and nucleotides form the …

In the human body, copper is an important trace element and is a cofactor for several
important enzymes involved in energy production, iron metabolism, neuropeptide activation …

Background Liver hepatocellular carcinoma (LIHC) ranks sixth among the most common
types of cancer with a high mortality rate. Cuproptosis is a newly discovered type of cell …