Epicardial adipose tissue may mediate deleterious effects of obesity and inflammation on the myocardium

M Packer - Journal of the American College of Cardiology, 2018 - jacc.org
Epicardial adipose tissue has unique properties that distinguish it from other depots of
visceral fat. Rather than having distinct boundaries, the epicardium shares an unobstructed …

Obesity-induced changes in adipose tissue microenvironment and their impact on cardiovascular disease

JJ Fuster, N Ouchi, N Gokce, K Walsh - Circulation research, 2016 - Am Heart Assoc
Obesity is causally linked with the development of cardiovascular disorders. Accumulating
evidence indicates that cardiovascular disease is the collateral damage of obesity-driven …

Epicardial adipose tissue: anatomic, biomolecular and clinical relationships with the heart

G Iacobellis, D Corradi, AM Sharma - Nature clinical practice …, 2005 - nature.com
A growing amount of evidence suggests that regional fat distribution plays an important part
in the development of an unfavorable metabolic and cardiovascular risk profile. Epicardial …

Pericardial fat, visceral abdominal fat, cardiovascular disease risk factors, and vascular calcification in a community-based sample: the Framingham Heart Study

GA Rosito, JM Massaro, U Hoffmann, FL Ruberg… - Circulation, 2008 - Am Heart Assoc
Background—Pericardial fat may be an important mediator of metabolic risk. Correlations
with cardiovascular disease risk factors and vascular calcification in a community-based …

Guidelines for the measurement of vascular function and structure in isolated arteries and veins

CF Wenceslau, CG McCarthy… - American Journal …, 2021 - journals.physiology.org
The measurement of vascular function in isolated vessels has revealed important insights
into the structural, functional, and biomechanical features of the normal and diseased …

The adipose organ

S Cinti - Adipose tissue and adipokines in health and disease, 2007 - Springer
Mammals are provided with an organ that has been neglected by scientists in the past: the
adipose organ. This organ is formed by a series of well-defined depots mainly located at two …

Mechanistic links between obesity, diabetes, and blood pressure: role of perivascular adipose tissue

SN Saxton, BJ Clark, SB Withers… - Physiological …, 2019 - journals.physiology.org
Obesity is increasingly prevalent and is associated with substantial cardiovascular risk.
Adipose tissue distribution and morphology play a key role in determining the degree of …

Perivascular adipose tissue inflammation in vascular disease

R Nosalski, TJ Guzik - British journal of pharmacology, 2017 - Wiley Online Library
Perivascular adipose tissue (PVAT) plays a critical role in the pathogenesis of
cardiovascular disease. In vascular pathologies, perivascular adipose tissue increases in …

Local inflammation and hypoxia abolish the protective anticontractile properties of perivascular fat in obese patients

AS Greenstein, K Khavandi, SB Withers, K Sonoyama… - Circulation, 2009 - Am Heart Assoc
Background—Inflammation in adipose tissue has been implicated in vascular dysfunction,
but the local mechanisms by which this occurs are unknown. Methods and Results—Small …

Newly identified regulators of ovarian folliculogenesis and ovulation

E Gershon, N Dekel - International journal of molecular sciences, 2020 - mdpi.com
Each follicle represents the basic functional unit of the ovary. From its very initial stage of
development, the follicle consists of an oocyte surrounded by somatic cells. The oocyte …