Recovery from disorders of consciousness: mechanisms, prognosis and emerging therapies

BL Edlow, J Claassen, ND Schiff… - Nature Reviews Neurology, 2021 - nature.com
Substantial progress has been made over the past two decades in detecting, predicting and
promoting recovery of consciousness in patients with disorders of consciousness (DoC) …

Are the neural correlates of consciousness in the front or in the back of the cerebral cortex? Clinical and neuroimaging evidence

M Boly, M Massimini, N Tsuchiya… - Journal of …, 2017 - Soc Neuroscience
The role of the frontal cortex in consciousness remains a matter of debate. In this
Perspective, we will critically review the clinical and neuroimaging evidence for the …

Thalamic deep brain stimulation in traumatic brain injury: a phase 1, randomized feasibility study

ND Schiff, JT Giacino, CR Butson, EY Choi, JL Baker… - Nature medicine, 2023 - nature.com
Converging evidence indicates that impairments in executive function and information-
processing speed limit quality of life and social reentry after moderate-to-severe traumatic …

Stratification of unresponsive patients by an independently validated index of brain complexity

S Casarotto, A Comanducci, M Rosanova… - Annals of …, 2016 - Wiley Online Library
Objective Validating objective, brain‐based indices of consciousness in behaviorally
unresponsive patients represents a challenge due to the impossibility of obtaining …

Disorders of consciousness after acquired brain injury: the state of the science

JT Giacino, JJ Fins, S Laureys, ND Schiff - Nature Reviews Neurology, 2014 - nature.com
The concept of consciousness continues to defy definition and elude the grasp of
philosophical and scientific efforts to formulate a testable construct that maps to human …

Large scale screening of neural signatures of consciousness in patients in a vegetative or minimally conscious state

JD Sitt, JR King, I El Karoui, B Rohaut, F Faugeras… - Brain, 2014 - academic.oup.com
In recent years, numerous electrophysiological signatures of consciousness have been
proposed. Here, we perform a systematic analysis of these electroencephalography markers …

Cognitive motor dissociation following severe brain injuries

ND Schiff - JAMA neurology, 2015 - jamanetwork.com
We have made tremendous strides in the treatment of relapsing-remitting MS since 1993. A
major problem confronting neurologists, our patients, and the US health care system is the …

Diagnostic precision of PET imaging and functional MRI in disorders of consciousness: a clinical validation study

J Stender, O Gosseries, MA Bruno, V Charland-Verville… - The Lancet, 2014 - thelancet.com
Background Bedside clinical examinations can have high rates of misdiagnosis of
unresponsive wakefulness syndrome (vegetative state) or minimally conscious state. The …

Entropy and the brain: An overview

S Keshmiri - Entropy, 2020 - mdpi.com
Entropy is a powerful tool for quantification of the brain function and its information
processing capacity. This is evident in its broad domain of applications that range from …

Information sharing in the brain indexes consciousness in noncommunicative patients

JR King, JD Sitt, F Faugeras, B Rohaut, I El Karoui… - Current biology, 2013 - cell.com
Neuronal theories of conscious access tentatively relate conscious perception to the
integration and global broadcasting of information across distant cortical and thalamic areas …