The blood brain barrier (BBB) presents a formidable challenge to the delivery of drugs into
the brain. Several strategies aim to overcome this obstacle and promote efficient and …

Cholesterol is an essential component of cell membranes and the precursor for the
synthesis of steroid hormones and bile acids. The synthesis of this molecule occurs partially …

Driven by chemistry but increasingly guided by pharmacology and the clinical sciences,
drug research has contributed more to the progress of medicine during the past century than …

In humans, low peak bone mass is a significant risk factor for osteoporosis. We report that
LRP5, encoding the low-density lipoprotein receptor-related protein 5, affects bone mass …

In a screen of drugs previously tested in humans we identified itraconazole, a systemic
antifungal, as a potent antagonist of the Hedgehog (Hh) signaling pathway that acts by a …

Osteoporosis is a complex disease that affects> 10 million people in the United States and
results in 1.5 million fractures annually. In addition, the high prevalence of osteopenia (low …

In the preface to the Second edition, we made a prediction that many exciting developments
would take place in the coming years that would change the face of a new edition. This has …

The low-density lipoprotein receptor–related protein (Lrp)-5 functions as a Wnt coreceptor.
Here we show that mice with a targeted disruption of Lrp5 develop a low bone mass …

The blood–brain barrier (BBB) restricts the entry of proteins as well as potential drugs to
cerebral tissues. We previously reported that a family of Kunitz domain‐derived peptides …

Liver sinusoidal endothelial cells (LSECs) are the most abundant non-parenchymal cells
lining the sinusoidal capillaries of the hepatic system. LSECs are characterized with …