[HTML][HTML] A 3′ external transcribed spacer in a tRNA transcript acts as a sponge for small RNAs to prevent transcriptional noise

D Lalaouna, MC Carrier, S Semsey, JS Brouard… - Molecular cell, 2015 - cell.com
During ribosomal and transfer RNA maturation, external transcribed spacer (ETS) and
internal transcribed spacer (ITS) sequences are excised and, as non-functional by-products …

Transcriptome data are insufficient to control false discoveries in regulatory network inference

E Kernfeld, R Keener, P Cahan, A Battle - Cell systems, 2024 - cell.com
Inference of causal transcriptional regulatory networks (TRNs) from transcriptomic data
suffers notoriously from false positives. Approaches to control the false discovery rate (FDR) …

The role of integration host factor in Escherichia coli persister formation

SE Nicolau, K Lewis - MBio, 2022 - Am Soc Microbiol
Persisters represent a small subpopulation of cells that are tolerant of killing by antibiotics
and are implicated in the recalcitrance of chronic infections to antibiotic therapy. One …

Stress response modulation: the key to survival of pathogenic and spoilage bacteria during poultry processing

M Marmion, G Macori, P Whyte… - Microbiology, 2022 - microbiologyresearch.org
The control of bacterial contaminants on meat is a key area of interest in the food industry.
Bacteria are exposed to a variety of stresses during broiler processing which challenge …

Unveiling the genetic basis and metabolic rewiring behind the galactose-positive phenotype in a Streptococcus thermophilus mutant

H Hu, Q Peng, J Tai, W Lu, J Liu, T Dan - Microbiological research, 2024 - Elsevier
Streptococcus thermophilus (S. thermophilus) is a widely used starter culture in dairy
fermentation, but most strains are galactose-negative and only metabolize glucose from …

Escherichia coli σ70 promoters allow expression rate control at the cellular level in genome-integrated expression systems

A Schuller, M Cserjan-Puschmann, C Tauer… - Microbial Cell …, 2020 - Springer
Background The genome-integrated T7 expression system offers significant advantages, in
terms of productivity and product quality, even when expressing the gene of interest (GOI) …

High-Level Production of Tyrosol with Noninduced Recombinant Escherichia coli by Metabolic Engineering

W Xu, C Yang, Y **a, L Zhang, C Liu… - Journal of agricultural …, 2020 - ACS Publications
Tyrosol is a pharmacologically active phenolic compound widely used in the pharmaceutical
and chemical industries. Microbial fermentation has potential value as an environmentally …

Quorum-sensing synchronization of synthetic toggle switches: A design based on monotone dynamical systems theory

EV Nikolaev, ED Sontag - PLoS computational biology, 2016 - journals.plos.org
Synthetic constructs in biotechnology, biocomputing, and modern gene therapy
interventions are often based on plasmids or transfected circuits which implement some form …

Distribution of fitness effects of mutations obtained from a simple genetic regulatory network model

RG Brajesh, D Dutta, S Saini - Scientific Reports, 2019 - nature.com
Beneficial and deleterious mutations change an organism's fitness but the distribution of
these mutational effects on fitness are unknown. Several experimental, theoretical, and …

Evaluation of double expression system for co-expression and co-immobilization of flavonoid glucosylation cascade

A Matera, K Dulak, S Sordon, K Waśniewski… - Applied Microbiology …, 2022 - Springer
Glucosylation cascade consisting of Leloir glycosyltransferase and sucrose synthase with in
situ regeneration system of expensive and low available nucleotide sugars is a game …